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High-density spinal cord stimulation selectively activates lower urinary tract nerves
Objective. Epidural spinal cord stimulation (SCS) is a potential intervention to improve limb and autonomic functions, with lumbar stimulation improving locomotion and thoracic stimulation regulating blood pressure. Here, we asked whether sacral SCS could be used to target the lower urinary tract (L...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOP Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855651/ https://www.ncbi.nlm.nih.gov/pubmed/36343359 http://dx.doi.org/10.1088/1741-2552/aca0c2 |
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author | Jantz, Maria K Gopinath, Chaitanya Kumar, Ritesh Chin, Celine Wong, Liane Ogren, John I Fisher, Lee E McLaughlin, Bryan L Gaunt, Robert A |
author_facet | Jantz, Maria K Gopinath, Chaitanya Kumar, Ritesh Chin, Celine Wong, Liane Ogren, John I Fisher, Lee E McLaughlin, Bryan L Gaunt, Robert A |
author_sort | Jantz, Maria K |
collection | PubMed |
description | Objective. Epidural spinal cord stimulation (SCS) is a potential intervention to improve limb and autonomic functions, with lumbar stimulation improving locomotion and thoracic stimulation regulating blood pressure. Here, we asked whether sacral SCS could be used to target the lower urinary tract (LUT) and used a high-density epidural electrode array to test whether individual electrodes could selectively recruit LUT nerves. Approach. We placed a high-density epidural SCS array on the dorsal surface of the sacral spinal cord and cauda equina of anesthetized cats and recorded the stimulation-evoked activity from nerve cuffs on the pelvic, pudendal and sciatic nerves. Main results. Here we show that sacral SCS evokes responses in nerves innervating the bladder and urethra and that these nerves can be activated selectively. Sacral SCS always recruited the pelvic and pudendal nerves and selectively recruited both of these nerves in all but one animal. Individual branches of the pudendal nerve were always recruited as well. Electrodes that selectively recruited specific peripheral nerves were spatially clustered on the arrays, suggesting anatomically organized sensory pathways. Significance. This selective recruitment demonstrates a mechanism to directly modulate bladder and urethral function through known reflex pathways, which could be used to restore bladder and urethral function after injury or disease. |
format | Online Article Text |
id | pubmed-9855651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IOP Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-98556512023-01-23 High-density spinal cord stimulation selectively activates lower urinary tract nerves Jantz, Maria K Gopinath, Chaitanya Kumar, Ritesh Chin, Celine Wong, Liane Ogren, John I Fisher, Lee E McLaughlin, Bryan L Gaunt, Robert A J Neural Eng Paper Objective. Epidural spinal cord stimulation (SCS) is a potential intervention to improve limb and autonomic functions, with lumbar stimulation improving locomotion and thoracic stimulation regulating blood pressure. Here, we asked whether sacral SCS could be used to target the lower urinary tract (LUT) and used a high-density epidural electrode array to test whether individual electrodes could selectively recruit LUT nerves. Approach. We placed a high-density epidural SCS array on the dorsal surface of the sacral spinal cord and cauda equina of anesthetized cats and recorded the stimulation-evoked activity from nerve cuffs on the pelvic, pudendal and sciatic nerves. Main results. Here we show that sacral SCS evokes responses in nerves innervating the bladder and urethra and that these nerves can be activated selectively. Sacral SCS always recruited the pelvic and pudendal nerves and selectively recruited both of these nerves in all but one animal. Individual branches of the pudendal nerve were always recruited as well. Electrodes that selectively recruited specific peripheral nerves were spatially clustered on the arrays, suggesting anatomically organized sensory pathways. Significance. This selective recruitment demonstrates a mechanism to directly modulate bladder and urethral function through known reflex pathways, which could be used to restore bladder and urethral function after injury or disease. IOP Publishing 2022-12-01 2022-11-22 /pmc/articles/PMC9855651/ /pubmed/36343359 http://dx.doi.org/10.1088/1741-2552/aca0c2 Text en © 2022 The Author(s). Published by IOP Publishing Ltd https://creativecommons.org/licenses/by/4.0/ Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license (https://creativecommons.org/licenses/by/4.0/) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
spellingShingle | Paper Jantz, Maria K Gopinath, Chaitanya Kumar, Ritesh Chin, Celine Wong, Liane Ogren, John I Fisher, Lee E McLaughlin, Bryan L Gaunt, Robert A High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title | High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title_full | High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title_fullStr | High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title_full_unstemmed | High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title_short | High-density spinal cord stimulation selectively activates lower urinary tract nerves |
title_sort | high-density spinal cord stimulation selectively activates lower urinary tract nerves |
topic | Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855651/ https://www.ncbi.nlm.nih.gov/pubmed/36343359 http://dx.doi.org/10.1088/1741-2552/aca0c2 |
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