Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury

ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to promote its transcriptional activity in the nucleus. However, whether cytoplasmic ASPP1 affects p53 nuclear trafficking and its role in cardiac diseases remains unknown. This study aims to...

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Detalles Bibliográficos
Autores principales: Yang, Ying, Zhang, Yang, Yang, Jiqin, Zhang, Manman, Tian, Tao, Jiang, Yuan, Liu, Xuening, Xue, Genlong, Li, Xingda, Zhang, Xiaofang, Li, Shangxuan, Huang, Xiang, Li, Zheng, Guo, Yang, Zhao, Lexin, Bao, Hairong, Zhou, Zhiwen, Song, Jiahui, Yang, Guohui, Xuan, Lina, Shan, Hongli, Zhang, Zhiren, Lu, Yanjie, Yang, Baofeng, Pan, Zhenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855749/
https://www.ncbi.nlm.nih.gov/pubmed/36656967
http://dx.doi.org/10.1161/CIRCRESAHA.122.321153

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