Genetic Predisposition to Neurological Complications in Patients with COVID-19

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological fu...

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Detalles Bibliográficos
Autores principales: Sahajpal, Nikhil Shri, Hastie, Alex R., Schieck, Maximilian, Mondal, Ashis K., Felde, Marc, van der Made, Caspar I., Chou, Janet S., Randolph, Adrienne G., Illig, Thomas, Zody, Michael C., Brownstein, Catherine A., Beggs, Alan H., Hoischen, Alexander, Chaubey, Alka, Kolhe, Ravindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855758/
https://www.ncbi.nlm.nih.gov/pubmed/36671517
http://dx.doi.org/10.3390/biom13010133
Descripción
Sumario:Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

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