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Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients

Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the rel...

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Autores principales: D’Ascanio, Michela, Viccaro, Fausta, Pizzirusso, Dario, Guerrieri, Giulio, Pagliuca, Alessandra, Guerrini, Simone, Innammorato, Marta, De Vitis, Claudia, Raffa, Salvatore, Pezzuto, Aldo, Ricci, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855771/
https://www.ncbi.nlm.nih.gov/pubmed/36672632
http://dx.doi.org/10.3390/biomedicines11010124
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author D’Ascanio, Michela
Viccaro, Fausta
Pizzirusso, Dario
Guerrieri, Giulio
Pagliuca, Alessandra
Guerrini, Simone
Innammorato, Marta
De Vitis, Claudia
Raffa, Salvatore
Pezzuto, Aldo
Ricci, Alberto
author_facet D’Ascanio, Michela
Viccaro, Fausta
Pizzirusso, Dario
Guerrieri, Giulio
Pagliuca, Alessandra
Guerrini, Simone
Innammorato, Marta
De Vitis, Claudia
Raffa, Salvatore
Pezzuto, Aldo
Ricci, Alberto
author_sort D’Ascanio, Michela
collection PubMed
description Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker.
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spelling pubmed-98557712023-01-21 Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients D’Ascanio, Michela Viccaro, Fausta Pizzirusso, Dario Guerrieri, Giulio Pagliuca, Alessandra Guerrini, Simone Innammorato, Marta De Vitis, Claudia Raffa, Salvatore Pezzuto, Aldo Ricci, Alberto Biomedicines Article Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker. MDPI 2023-01-04 /pmc/articles/PMC9855771/ /pubmed/36672632 http://dx.doi.org/10.3390/biomedicines11010124 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Ascanio, Michela
Viccaro, Fausta
Pizzirusso, Dario
Guerrieri, Giulio
Pagliuca, Alessandra
Guerrini, Simone
Innammorato, Marta
De Vitis, Claudia
Raffa, Salvatore
Pezzuto, Aldo
Ricci, Alberto
Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title_full Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title_fullStr Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title_full_unstemmed Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title_short Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
title_sort surfactant protein b plasma levels: reliability as a biomarker in copd patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855771/
https://www.ncbi.nlm.nih.gov/pubmed/36672632
http://dx.doi.org/10.3390/biomedicines11010124
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