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Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients
Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the rel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855771/ https://www.ncbi.nlm.nih.gov/pubmed/36672632 http://dx.doi.org/10.3390/biomedicines11010124 |
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author | D’Ascanio, Michela Viccaro, Fausta Pizzirusso, Dario Guerrieri, Giulio Pagliuca, Alessandra Guerrini, Simone Innammorato, Marta De Vitis, Claudia Raffa, Salvatore Pezzuto, Aldo Ricci, Alberto |
author_facet | D’Ascanio, Michela Viccaro, Fausta Pizzirusso, Dario Guerrieri, Giulio Pagliuca, Alessandra Guerrini, Simone Innammorato, Marta De Vitis, Claudia Raffa, Salvatore Pezzuto, Aldo Ricci, Alberto |
author_sort | D’Ascanio, Michela |
collection | PubMed |
description | Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker. |
format | Online Article Text |
id | pubmed-9855771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98557712023-01-21 Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients D’Ascanio, Michela Viccaro, Fausta Pizzirusso, Dario Guerrieri, Giulio Pagliuca, Alessandra Guerrini, Simone Innammorato, Marta De Vitis, Claudia Raffa, Salvatore Pezzuto, Aldo Ricci, Alberto Biomedicines Article Background: The diagnosis of COPD is based on both clinical signs and functional tests. Although there are different functional tests used to assess COPD, no reliable biomarkers able to provide information on pathogenesis and severity are available. The aim of the present study is to explore the relationship between surfactant protein B (Sp-B) serum levels and clinical, radiological, and functional pulmonary parameters in COPD patients. Methods: Forty COPD patients and twenty smokers without airflow limitations or respiratory symptoms were enrolled. Each patient was given questionnaires (CAT and mMRC) and 6MWT, spirometry, DLCO, and computer tomography (CT) were performed. All participants underwent a venous blood sample drawing, and quantitative detection of their Sp-B plasma levels was performed by an enzyme-linked immunosorbent assay. The spirometry and Sp-B plasma levels were assessed after 12 months. Results: A statistically significant difference was found in the plasma Sp-B levels between COPD patients compared to the other group (4.72 + 3.2 ng/mL vs. 1.78 + 1.5 ng/mL; p < 0.001). The change in FEV1 after 12 months (Delta FEV1) showed a significantly negative correlation with respect to the change in Sp-B levels (Delta SpB) (r = −0.4; p < 0.05). This correlation indicates that increasing the plasma dosage of SpB is a foretoken of functional decline. Conclusions: SpB may be considered as a useful marker in COPD assessment and provides prognostic information on lung functional decline. Despite its usefulness, further studies are needed to define its reliability as a biomarker. MDPI 2023-01-04 /pmc/articles/PMC9855771/ /pubmed/36672632 http://dx.doi.org/10.3390/biomedicines11010124 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article D’Ascanio, Michela Viccaro, Fausta Pizzirusso, Dario Guerrieri, Giulio Pagliuca, Alessandra Guerrini, Simone Innammorato, Marta De Vitis, Claudia Raffa, Salvatore Pezzuto, Aldo Ricci, Alberto Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title | Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title_full | Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title_fullStr | Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title_full_unstemmed | Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title_short | Surfactant Protein B Plasma Levels: Reliability as a Biomarker in COPD Patients |
title_sort | surfactant protein b plasma levels: reliability as a biomarker in copd patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855771/ https://www.ncbi.nlm.nih.gov/pubmed/36672632 http://dx.doi.org/10.3390/biomedicines11010124 |
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