Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives

SIMPLE SUMMARY: Infertility is a global issue and the currently available treatments for infertility are known to pose some risks and are lacking in solving infertility problems that are closely related to genetic disorders. In this review, we summarized the use of autologous mesenchymal stem cells (MSCs) as the cell-based treatment for infertility and the future treatments of infertility using various methods. ABSTRACT: Infertility could be associated with a few factors including problems with physical and mental health, hormonal imbalances, lifestyles, and genetic factors. Given that there is a concern about the rise of infertility globally, increased focus has been given to its treatment for the last several decades. Traditional assisted reproductive technology (ART) has been the prime option for many years in solving various cases of infertility; however, it contains significant risks and does not solve the fundamental problem of infertility such as genetic disorders. Attention toward the utilization of MSCs has been widely regarded as a promising option in the development of stem-cell-based infertility treatments. This narrative review briefly presents the challenges in the current ART treatment of infertility and the various potential applications of autologous MSCs in the treatment of these reproductive diseases.