C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo

We previously demonstrated that a synthetic monomer peptide derived from the C-terminus of p53 (aa 361–382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. The major problem with the peptide was its short half-life (half-life < 10 min.) due to a random coil top...

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Detalles Bibliográficos
Autores principales: Fine, Robert L., Mao, Yuehua, Dinnen, Richard, Rosal, Ramon V., Raffo, Anthony, Hochfeld, Uri, Senatus, Patrick, Bruce, Jeffrey N., Nichols, Gwen, Wang, Hsin, Li, Yongliang, Brandt-Rauf, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855826/
https://www.ncbi.nlm.nih.gov/pubmed/36672645
http://dx.doi.org/10.3390/biomedicines11010137

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