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Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia

Epidemiological studies and clinical observations show evidence of sexual dimorphism in brain responses to several neurological conditions. It is suggested that sex-related differences between men and women may have profound effects on disease susceptibility, pathophysiology, and progression. Sexual...

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Autores principales: Zalewska, Teresa, Pawelec, Paulina, Ziabska, Karolina, Ziemka-Nalecz, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855831/
https://www.ncbi.nlm.nih.gov/pubmed/36671411
http://dx.doi.org/10.3390/biom13010026
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author Zalewska, Teresa
Pawelec, Paulina
Ziabska, Karolina
Ziemka-Nalecz, Malgorzata
author_facet Zalewska, Teresa
Pawelec, Paulina
Ziabska, Karolina
Ziemka-Nalecz, Malgorzata
author_sort Zalewska, Teresa
collection PubMed
description Epidemiological studies and clinical observations show evidence of sexual dimorphism in brain responses to several neurological conditions. It is suggested that sex-related differences between men and women may have profound effects on disease susceptibility, pathophysiology, and progression. Sexual differences of the brain are achieved through the complex interplay of several factors contributing to this phenomenon, such as sex hormones, as well as genetic and epigenetic differences. Despite recent advances, the precise link between these factors and brain disorders is incompletely understood. This review aims to briefly outline the most relevant aspects that differ between men and women in ischemia and neurodegenerative disorders (AD, PD, HD, ALS, and SM). Recognition of disparities between both sexes could aid the development of individual approaches to ameliorate or slow the progression of intractable disorders.
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spelling pubmed-98558312023-01-21 Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia Zalewska, Teresa Pawelec, Paulina Ziabska, Karolina Ziemka-Nalecz, Malgorzata Biomolecules Review Epidemiological studies and clinical observations show evidence of sexual dimorphism in brain responses to several neurological conditions. It is suggested that sex-related differences between men and women may have profound effects on disease susceptibility, pathophysiology, and progression. Sexual differences of the brain are achieved through the complex interplay of several factors contributing to this phenomenon, such as sex hormones, as well as genetic and epigenetic differences. Despite recent advances, the precise link between these factors and brain disorders is incompletely understood. This review aims to briefly outline the most relevant aspects that differ between men and women in ischemia and neurodegenerative disorders (AD, PD, HD, ALS, and SM). Recognition of disparities between both sexes could aid the development of individual approaches to ameliorate or slow the progression of intractable disorders. MDPI 2022-12-22 /pmc/articles/PMC9855831/ /pubmed/36671411 http://dx.doi.org/10.3390/biom13010026 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zalewska, Teresa
Pawelec, Paulina
Ziabska, Karolina
Ziemka-Nalecz, Malgorzata
Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title_full Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title_fullStr Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title_full_unstemmed Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title_short Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
title_sort sexual dimorphism in neurodegenerative diseases and in brain ischemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855831/
https://www.ncbi.nlm.nih.gov/pubmed/36671411
http://dx.doi.org/10.3390/biom13010026
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