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Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients
Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855909/ https://www.ncbi.nlm.nih.gov/pubmed/36671458 http://dx.doi.org/10.3390/biom13010073 |
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author | Gómez-Bernal, Fuensanta Quevedo-Abeledo, Juan Carlos García-González, María Fernández-Cladera, Yolanda González-Rivero, Agustín F. de Vera-González, Antonia Martín-González, Candelaria González-Gay, Miguel Á. Ferraz-Amaro, Iván |
author_facet | Gómez-Bernal, Fuensanta Quevedo-Abeledo, Juan Carlos García-González, María Fernández-Cladera, Yolanda González-Rivero, Agustín F. de Vera-González, Antonia Martín-González, Candelaria González-Gay, Miguel Á. Ferraz-Amaro, Iván |
author_sort | Gómez-Bernal, Fuensanta |
collection | PubMed |
description | Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7–350] pg/mL, p = 0.041) and SLEDAI activity index (beta coefficient 96 [95% CI 20–171] pg/mL, p = 0.014) were associated with higher serum levels of TGF-β1 after the multivariable analysis. When the disease-specific features were studied, ocular and cardiovascular manifestations were positively associated with serum TGF-β1 levels. In contrast, gastrointestinal and musculoskeletal involvements were associated with lower levels of circulating TGF-β1. Among patients with SLE, the serum levels of TGF-β1 were highly associated with disease-related manifestations. |
format | Online Article Text |
id | pubmed-9855909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98559092023-01-21 Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients Gómez-Bernal, Fuensanta Quevedo-Abeledo, Juan Carlos García-González, María Fernández-Cladera, Yolanda González-Rivero, Agustín F. de Vera-González, Antonia Martín-González, Candelaria González-Gay, Miguel Á. Ferraz-Amaro, Iván Biomolecules Article Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7–350] pg/mL, p = 0.041) and SLEDAI activity index (beta coefficient 96 [95% CI 20–171] pg/mL, p = 0.014) were associated with higher serum levels of TGF-β1 after the multivariable analysis. When the disease-specific features were studied, ocular and cardiovascular manifestations were positively associated with serum TGF-β1 levels. In contrast, gastrointestinal and musculoskeletal involvements were associated with lower levels of circulating TGF-β1. Among patients with SLE, the serum levels of TGF-β1 were highly associated with disease-related manifestations. MDPI 2022-12-29 /pmc/articles/PMC9855909/ /pubmed/36671458 http://dx.doi.org/10.3390/biom13010073 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gómez-Bernal, Fuensanta Quevedo-Abeledo, Juan Carlos García-González, María Fernández-Cladera, Yolanda González-Rivero, Agustín F. de Vera-González, Antonia Martín-González, Candelaria González-Gay, Miguel Á. Ferraz-Amaro, Iván Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title | Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title_full | Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title_fullStr | Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title_full_unstemmed | Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title_short | Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients |
title_sort | serum levels of transforming growth factor beta 1 in systemic lupus erythematosus patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855909/ https://www.ncbi.nlm.nih.gov/pubmed/36671458 http://dx.doi.org/10.3390/biom13010073 |
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