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Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855938/ https://www.ncbi.nlm.nih.gov/pubmed/36671442 http://dx.doi.org/10.3390/biom13010057 |
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author | Tuli, Hardeep Singh Rath, Prangya Chauhan, Abhishek Ranjan, Anuj Ramniwas, Seema Sak, Katrin Aggarwal, Diwakar Kumar, Manoj Dhama, Kuldeep Lee, E Hui Clarissa Yap, Kenneth Chun-Yong Capinpin, Sharah Mae Kumar, Alan Prem |
author_facet | Tuli, Hardeep Singh Rath, Prangya Chauhan, Abhishek Ranjan, Anuj Ramniwas, Seema Sak, Katrin Aggarwal, Diwakar Kumar, Manoj Dhama, Kuldeep Lee, E Hui Clarissa Yap, Kenneth Chun-Yong Capinpin, Sharah Mae Kumar, Alan Prem |
author_sort | Tuli, Hardeep Singh |
collection | PubMed |
description | Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium. |
format | Online Article Text |
id | pubmed-9855938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98559382023-01-21 Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends Tuli, Hardeep Singh Rath, Prangya Chauhan, Abhishek Ranjan, Anuj Ramniwas, Seema Sak, Katrin Aggarwal, Diwakar Kumar, Manoj Dhama, Kuldeep Lee, E Hui Clarissa Yap, Kenneth Chun-Yong Capinpin, Sharah Mae Kumar, Alan Prem Biomolecules Review Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium. MDPI 2022-12-27 /pmc/articles/PMC9855938/ /pubmed/36671442 http://dx.doi.org/10.3390/biom13010057 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tuli, Hardeep Singh Rath, Prangya Chauhan, Abhishek Ranjan, Anuj Ramniwas, Seema Sak, Katrin Aggarwal, Diwakar Kumar, Manoj Dhama, Kuldeep Lee, E Hui Clarissa Yap, Kenneth Chun-Yong Capinpin, Sharah Mae Kumar, Alan Prem Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title_full | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title_fullStr | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title_full_unstemmed | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title_short | Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends |
title_sort | cucurbitacins as potent chemo-preventive agents: mechanistic insight and recent trends |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855938/ https://www.ncbi.nlm.nih.gov/pubmed/36671442 http://dx.doi.org/10.3390/biom13010057 |
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