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Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends

Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested t...

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Autores principales: Tuli, Hardeep Singh, Rath, Prangya, Chauhan, Abhishek, Ranjan, Anuj, Ramniwas, Seema, Sak, Katrin, Aggarwal, Diwakar, Kumar, Manoj, Dhama, Kuldeep, Lee, E Hui Clarissa, Yap, Kenneth Chun-Yong, Capinpin, Sharah Mae, Kumar, Alan Prem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855938/
https://www.ncbi.nlm.nih.gov/pubmed/36671442
http://dx.doi.org/10.3390/biom13010057
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author Tuli, Hardeep Singh
Rath, Prangya
Chauhan, Abhishek
Ranjan, Anuj
Ramniwas, Seema
Sak, Katrin
Aggarwal, Diwakar
Kumar, Manoj
Dhama, Kuldeep
Lee, E Hui Clarissa
Yap, Kenneth Chun-Yong
Capinpin, Sharah Mae
Kumar, Alan Prem
author_facet Tuli, Hardeep Singh
Rath, Prangya
Chauhan, Abhishek
Ranjan, Anuj
Ramniwas, Seema
Sak, Katrin
Aggarwal, Diwakar
Kumar, Manoj
Dhama, Kuldeep
Lee, E Hui Clarissa
Yap, Kenneth Chun-Yong
Capinpin, Sharah Mae
Kumar, Alan Prem
author_sort Tuli, Hardeep Singh
collection PubMed
description Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.
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spelling pubmed-98559382023-01-21 Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends Tuli, Hardeep Singh Rath, Prangya Chauhan, Abhishek Ranjan, Anuj Ramniwas, Seema Sak, Katrin Aggarwal, Diwakar Kumar, Manoj Dhama, Kuldeep Lee, E Hui Clarissa Yap, Kenneth Chun-Yong Capinpin, Sharah Mae Kumar, Alan Prem Biomolecules Review Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium. MDPI 2022-12-27 /pmc/articles/PMC9855938/ /pubmed/36671442 http://dx.doi.org/10.3390/biom13010057 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tuli, Hardeep Singh
Rath, Prangya
Chauhan, Abhishek
Ranjan, Anuj
Ramniwas, Seema
Sak, Katrin
Aggarwal, Diwakar
Kumar, Manoj
Dhama, Kuldeep
Lee, E Hui Clarissa
Yap, Kenneth Chun-Yong
Capinpin, Sharah Mae
Kumar, Alan Prem
Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title_full Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title_fullStr Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title_full_unstemmed Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title_short Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
title_sort cucurbitacins as potent chemo-preventive agents: mechanistic insight and recent trends
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855938/
https://www.ncbi.nlm.nih.gov/pubmed/36671442
http://dx.doi.org/10.3390/biom13010057
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