Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression

Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Addi...

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Detalles Bibliográficos
Autores principales: Reyes, Amanda, Mohanty, Atish, Pharaon, Rebecca, Massarelli, Erminia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856025/
https://www.ncbi.nlm.nih.gov/pubmed/36672607
http://dx.doi.org/10.3390/biomedicines11010099
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author Reyes, Amanda
Mohanty, Atish
Pharaon, Rebecca
Massarelli, Erminia
author_facet Reyes, Amanda
Mohanty, Atish
Pharaon, Rebecca
Massarelli, Erminia
author_sort Reyes, Amanda
collection PubMed
description Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors.
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spelling pubmed-98560252023-01-21 Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression Reyes, Amanda Mohanty, Atish Pharaon, Rebecca Massarelli, Erminia Biomedicines Review Autoimmunity and cancer rates have both been on the rise in Western civilization prompting many to investigate the link between the two entities. This review will investigate the complex interactions between the activation and deactivation of the immune system and the development of malignancy. Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors. MDPI 2022-12-30 /pmc/articles/PMC9856025/ /pubmed/36672607 http://dx.doi.org/10.3390/biomedicines11010099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reyes, Amanda
Mohanty, Atish
Pharaon, Rebecca
Massarelli, Erminia
Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title_full Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title_fullStr Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title_full_unstemmed Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title_short Association between Immunosuppressive Therapy Utilized in the Treatment of Autoimmune Disease or Transplant and Cancer Progression
title_sort association between immunosuppressive therapy utilized in the treatment of autoimmune disease or transplant and cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856025/
https://www.ncbi.nlm.nih.gov/pubmed/36672607
http://dx.doi.org/10.3390/biomedicines11010099
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