PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds

Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown...

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Detalles Bibliográficos
Autores principales: Yuan, Yeqin, Long, Huizhi, Zhou, Ziwei, Fu, Yuting, Jiang, Binyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856042/
https://www.ncbi.nlm.nih.gov/pubmed/36671478
http://dx.doi.org/10.3390/biom13010093
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author Yuan, Yeqin
Long, Huizhi
Zhou, Ziwei
Fu, Yuting
Jiang, Binyuan
author_facet Yuan, Yeqin
Long, Huizhi
Zhou, Ziwei
Fu, Yuting
Jiang, Binyuan
author_sort Yuan, Yeqin
collection PubMed
description Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K–AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K–AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K–AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer.
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spelling pubmed-98560422023-01-21 PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds Yuan, Yeqin Long, Huizhi Zhou, Ziwei Fu, Yuting Jiang, Binyuan Biomolecules Review Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K–AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K–AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K–AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer. MDPI 2023-01-02 /pmc/articles/PMC9856042/ /pubmed/36671478 http://dx.doi.org/10.3390/biom13010093 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yuan, Yeqin
Long, Huizhi
Zhou, Ziwei
Fu, Yuting
Jiang, Binyuan
PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title_full PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title_fullStr PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title_full_unstemmed PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title_short PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
title_sort pi3k–akt-targeting breast cancer treatments: natural products and synthetic compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856042/
https://www.ncbi.nlm.nih.gov/pubmed/36671478
http://dx.doi.org/10.3390/biom13010093
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AT zhouziwei pi3kakttargetingbreastcancertreatmentsnaturalproductsandsyntheticcompounds
AT fuyuting pi3kakttargetingbreastcancertreatmentsnaturalproductsandsyntheticcompounds
AT jiangbinyuan pi3kakttargetingbreastcancertreatmentsnaturalproductsandsyntheticcompounds

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