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Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs. Advances in microfluidic technologies have made a significant impact on the biomedical field. Specifically, organ-on-a-chip technology (OoC),...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856111/ https://www.ncbi.nlm.nih.gov/pubmed/36671971 http://dx.doi.org/10.3390/bios13010136 |
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author | Thomas, Dimple Palanilkunnathil Zhang, Jun Nguyen, Nam-Trung Ta, Hang Thu |
author_facet | Thomas, Dimple Palanilkunnathil Zhang, Jun Nguyen, Nam-Trung Ta, Hang Thu |
author_sort | Thomas, Dimple Palanilkunnathil |
collection | PubMed |
description | The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs. Advances in microfluidic technologies have made a significant impact on the biomedical field. Specifically, organ-on-a-chip technology (OoC), which has become a popular substitute for animal models, is capable of imitating complex systems in vitro and has been used to study pathology and pharmacology. Over the past decade, reviews published focused more on the applications and prospects of gut-on-a-chip (GOC) technology, but the challenges and solutions to these limitations were often overlooked. In this review, we cover the physiology of the human gut and review the engineering approaches of GOC. Fundamentals of GOC models including materials and fabrication, cell types, stimuli and gut microbiota are thoroughly reviewed. We discuss the present GOC model applications, challenges, possible solutions and prospects for the GOC models and technology. |
format | Online Article Text |
id | pubmed-9856111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98561112023-01-21 Microfluidic Gut-on-a-Chip: Fundamentals and Challenges Thomas, Dimple Palanilkunnathil Zhang, Jun Nguyen, Nam-Trung Ta, Hang Thu Biosensors (Basel) Review The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs. Advances in microfluidic technologies have made a significant impact on the biomedical field. Specifically, organ-on-a-chip technology (OoC), which has become a popular substitute for animal models, is capable of imitating complex systems in vitro and has been used to study pathology and pharmacology. Over the past decade, reviews published focused more on the applications and prospects of gut-on-a-chip (GOC) technology, but the challenges and solutions to these limitations were often overlooked. In this review, we cover the physiology of the human gut and review the engineering approaches of GOC. Fundamentals of GOC models including materials and fabrication, cell types, stimuli and gut microbiota are thoroughly reviewed. We discuss the present GOC model applications, challenges, possible solutions and prospects for the GOC models and technology. MDPI 2023-01-13 /pmc/articles/PMC9856111/ /pubmed/36671971 http://dx.doi.org/10.3390/bios13010136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Thomas, Dimple Palanilkunnathil Zhang, Jun Nguyen, Nam-Trung Ta, Hang Thu Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title | Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title_full | Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title_fullStr | Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title_full_unstemmed | Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title_short | Microfluidic Gut-on-a-Chip: Fundamentals and Challenges |
title_sort | microfluidic gut-on-a-chip: fundamentals and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856111/ https://www.ncbi.nlm.nih.gov/pubmed/36671971 http://dx.doi.org/10.3390/bios13010136 |
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