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Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight
Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mutate their genome to become more complex...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856122/ https://www.ncbi.nlm.nih.gov/pubmed/36671402 http://dx.doi.org/10.3390/biom13010017 |
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author | Sharma, Divya Sharma, Neetika Manchanda, Namish Prasad, Satyendra K. Sharma, Prabodh Chander Thakur, Vijay Kumar Rahman, M. Mukhlesur Dhobi, Mahaveer |
author_facet | Sharma, Divya Sharma, Neetika Manchanda, Namish Prasad, Satyendra K. Sharma, Prabodh Chander Thakur, Vijay Kumar Rahman, M. Mukhlesur Dhobi, Mahaveer |
author_sort | Sharma, Divya |
collection | PubMed |
description | Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mutate their genome to become more complex and resistant. Medicinal plants and phytocompounds could be alternative options. Isoquinoline and their related alkaloids are naturally occurring compounds that interfere with multiple pathways including nuclear factor-κB, mitogen-activated protein kinase/extracellular-signal-regulated kinase, and inhibition of Ca(2+)-mediated fusion. These pathways play a crucial role in viral replication. Thus, the major goal of this study is to comprehend the function of various isoquinoline and related alkaloids in viral infections by examining their potential mechanisms of action, structure-activity relationships (SAR), in silico (particularly for SARS-CoV-2), in vitro and in vivo studies. The current advancements in isoquinoline and related alkaloids as discussed in the present review could facilitate an in-depth understanding of their role in the drug discovery process. |
format | Online Article Text |
id | pubmed-9856122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98561222023-01-21 Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight Sharma, Divya Sharma, Neetika Manchanda, Namish Prasad, Satyendra K. Sharma, Prabodh Chander Thakur, Vijay Kumar Rahman, M. Mukhlesur Dhobi, Mahaveer Biomolecules Review Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mutate their genome to become more complex and resistant. Medicinal plants and phytocompounds could be alternative options. Isoquinoline and their related alkaloids are naturally occurring compounds that interfere with multiple pathways including nuclear factor-κB, mitogen-activated protein kinase/extracellular-signal-regulated kinase, and inhibition of Ca(2+)-mediated fusion. These pathways play a crucial role in viral replication. Thus, the major goal of this study is to comprehend the function of various isoquinoline and related alkaloids in viral infections by examining their potential mechanisms of action, structure-activity relationships (SAR), in silico (particularly for SARS-CoV-2), in vitro and in vivo studies. The current advancements in isoquinoline and related alkaloids as discussed in the present review could facilitate an in-depth understanding of their role in the drug discovery process. MDPI 2022-12-21 /pmc/articles/PMC9856122/ /pubmed/36671402 http://dx.doi.org/10.3390/biom13010017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sharma, Divya Sharma, Neetika Manchanda, Namish Prasad, Satyendra K. Sharma, Prabodh Chander Thakur, Vijay Kumar Rahman, M. Mukhlesur Dhobi, Mahaveer Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title | Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title_full | Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title_fullStr | Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title_full_unstemmed | Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title_short | Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight |
title_sort | bioactivity and in silico studies of isoquinoline and related alkaloids as promising antiviral agents: an insight |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856122/ https://www.ncbi.nlm.nih.gov/pubmed/36671402 http://dx.doi.org/10.3390/biom13010017 |
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