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Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive imp...

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Autores principales: Mellen, Rodrigo Haber, Girotto, Otávio Simões, Marques, Eduarda Boni, Laurindo, Lucas Fornari, Grippa, Paulo Cesar, Mendes, Claudemir Gregório, Garcia, Lorena Natalino Haber, Bechara, Marcelo Dib, Barbalho, Sandra Maria, Sinatora, Renata Vargas, Haber, Jesselina Francisco dos Santos, Flato, Uri Adrian P., Bueno, Patricia Cincotto dos Santos, Detregiachi, Claudia Rucco Penteado, Quesada, Karina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856128/
https://www.ncbi.nlm.nih.gov/pubmed/36672642
http://dx.doi.org/10.3390/biomedicines11010136
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author Mellen, Rodrigo Haber
Girotto, Otávio Simões
Marques, Eduarda Boni
Laurindo, Lucas Fornari
Grippa, Paulo Cesar
Mendes, Claudemir Gregório
Garcia, Lorena Natalino Haber
Bechara, Marcelo Dib
Barbalho, Sandra Maria
Sinatora, Renata Vargas
Haber, Jesselina Francisco dos Santos
Flato, Uri Adrian P.
Bueno, Patricia Cincotto dos Santos
Detregiachi, Claudia Rucco Penteado
Quesada, Karina
author_facet Mellen, Rodrigo Haber
Girotto, Otávio Simões
Marques, Eduarda Boni
Laurindo, Lucas Fornari
Grippa, Paulo Cesar
Mendes, Claudemir Gregório
Garcia, Lorena Natalino Haber
Bechara, Marcelo Dib
Barbalho, Sandra Maria
Sinatora, Renata Vargas
Haber, Jesselina Francisco dos Santos
Flato, Uri Adrian P.
Bueno, Patricia Cincotto dos Santos
Detregiachi, Claudia Rucco Penteado
Quesada, Karina
author_sort Mellen, Rodrigo Haber
collection PubMed
description Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles.
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spelling pubmed-98561282023-01-21 Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review Mellen, Rodrigo Haber Girotto, Otávio Simões Marques, Eduarda Boni Laurindo, Lucas Fornari Grippa, Paulo Cesar Mendes, Claudemir Gregório Garcia, Lorena Natalino Haber Bechara, Marcelo Dib Barbalho, Sandra Maria Sinatora, Renata Vargas Haber, Jesselina Francisco dos Santos Flato, Uri Adrian P. Bueno, Patricia Cincotto dos Santos Detregiachi, Claudia Rucco Penteado Quesada, Karina Biomedicines Systematic Review Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles. MDPI 2023-01-05 /pmc/articles/PMC9856128/ /pubmed/36672642 http://dx.doi.org/10.3390/biomedicines11010136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Mellen, Rodrigo Haber
Girotto, Otávio Simões
Marques, Eduarda Boni
Laurindo, Lucas Fornari
Grippa, Paulo Cesar
Mendes, Claudemir Gregório
Garcia, Lorena Natalino Haber
Bechara, Marcelo Dib
Barbalho, Sandra Maria
Sinatora, Renata Vargas
Haber, Jesselina Francisco dos Santos
Flato, Uri Adrian P.
Bueno, Patricia Cincotto dos Santos
Detregiachi, Claudia Rucco Penteado
Quesada, Karina
Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title_full Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title_fullStr Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title_full_unstemmed Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title_short Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
title_sort insights into pathogenesis, nutritional and drug approach in sarcopenia: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856128/
https://www.ncbi.nlm.nih.gov/pubmed/36672642
http://dx.doi.org/10.3390/biomedicines11010136
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