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Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive imp...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856128/ https://www.ncbi.nlm.nih.gov/pubmed/36672642 http://dx.doi.org/10.3390/biomedicines11010136 |
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author | Mellen, Rodrigo Haber Girotto, Otávio Simões Marques, Eduarda Boni Laurindo, Lucas Fornari Grippa, Paulo Cesar Mendes, Claudemir Gregório Garcia, Lorena Natalino Haber Bechara, Marcelo Dib Barbalho, Sandra Maria Sinatora, Renata Vargas Haber, Jesselina Francisco dos Santos Flato, Uri Adrian P. Bueno, Patricia Cincotto dos Santos Detregiachi, Claudia Rucco Penteado Quesada, Karina |
author_facet | Mellen, Rodrigo Haber Girotto, Otávio Simões Marques, Eduarda Boni Laurindo, Lucas Fornari Grippa, Paulo Cesar Mendes, Claudemir Gregório Garcia, Lorena Natalino Haber Bechara, Marcelo Dib Barbalho, Sandra Maria Sinatora, Renata Vargas Haber, Jesselina Francisco dos Santos Flato, Uri Adrian P. Bueno, Patricia Cincotto dos Santos Detregiachi, Claudia Rucco Penteado Quesada, Karina |
author_sort | Mellen, Rodrigo Haber |
collection | PubMed |
description | Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles. |
format | Online Article Text |
id | pubmed-9856128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98561282023-01-21 Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review Mellen, Rodrigo Haber Girotto, Otávio Simões Marques, Eduarda Boni Laurindo, Lucas Fornari Grippa, Paulo Cesar Mendes, Claudemir Gregório Garcia, Lorena Natalino Haber Bechara, Marcelo Dib Barbalho, Sandra Maria Sinatora, Renata Vargas Haber, Jesselina Francisco dos Santos Flato, Uri Adrian P. Bueno, Patricia Cincotto dos Santos Detregiachi, Claudia Rucco Penteado Quesada, Karina Biomedicines Systematic Review Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles. MDPI 2023-01-05 /pmc/articles/PMC9856128/ /pubmed/36672642 http://dx.doi.org/10.3390/biomedicines11010136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Mellen, Rodrigo Haber Girotto, Otávio Simões Marques, Eduarda Boni Laurindo, Lucas Fornari Grippa, Paulo Cesar Mendes, Claudemir Gregório Garcia, Lorena Natalino Haber Bechara, Marcelo Dib Barbalho, Sandra Maria Sinatora, Renata Vargas Haber, Jesselina Francisco dos Santos Flato, Uri Adrian P. Bueno, Patricia Cincotto dos Santos Detregiachi, Claudia Rucco Penteado Quesada, Karina Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title_full | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title_fullStr | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title_full_unstemmed | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title_short | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
title_sort | insights into pathogenesis, nutritional and drug approach in sarcopenia: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856128/ https://www.ncbi.nlm.nih.gov/pubmed/36672642 http://dx.doi.org/10.3390/biomedicines11010136 |
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