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Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma

Most patients with childhood asthma present their first symptoms at preschool age. Identifying modifiable risks and protective factors at an early age may help develop asthma prevention and control strategies. This study aimed to identify factors at preschool age that are associated with persistent...

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Autores principales: Sirianansopa, Kantisa, Ruangnapa, Kanokpan, Prasertsan, Pharsai, Saelim, Kantara, Anuntaseree, Wanaporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856300/
https://www.ncbi.nlm.nih.gov/pubmed/36670584
http://dx.doi.org/10.3390/children10010033
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author Sirianansopa, Kantisa
Ruangnapa, Kanokpan
Prasertsan, Pharsai
Saelim, Kantara
Anuntaseree, Wanaporn
author_facet Sirianansopa, Kantisa
Ruangnapa, Kanokpan
Prasertsan, Pharsai
Saelim, Kantara
Anuntaseree, Wanaporn
author_sort Sirianansopa, Kantisa
collection PubMed
description Most patients with childhood asthma present their first symptoms at preschool age. Identifying modifiable risks and protective factors at an early age may help develop asthma prevention and control strategies. This study aimed to identify factors at preschool age that are associated with persistent asthma at school age. This retrospective observational study included preschool children with asthma from 2015 to 2020 at a university hospital in Southern Thailand. In total, 189 eligible participants (70.9% boys; median age, 7.6 [6.7, 8.5] years) were included. Wheeze characteristics included early transient wheeze, persistent wheeze, and late-onset wheeze that accounted for 55%, 27.5%, and 19.5% of the patients, respectively. Approximately 20% of the participants had persistent asthma. Breastfeeding was a protective factor (odds ratio [OR] 0.4 [0.2, 0.9], p = 0.04). The modifiable risk factors were siblings living in the same household (OR 2.6 [1.1, 6.2], p = 0.02) and residence in an industrial area (OR 3.8 [1.4, 10.5], p = 0.009). Additionally, presence of allergic rhinitis was associated with an increased risk of persistent asthma at school age (OR 3.6 [1.6, 8.2], p = 0.002). Early therapeutic interventions targeting modifiable factors provide a window of opportunity to prevent persistent asthma at school age.
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spelling pubmed-98563002023-01-21 Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma Sirianansopa, Kantisa Ruangnapa, Kanokpan Prasertsan, Pharsai Saelim, Kantara Anuntaseree, Wanaporn Children (Basel) Article Most patients with childhood asthma present their first symptoms at preschool age. Identifying modifiable risks and protective factors at an early age may help develop asthma prevention and control strategies. This study aimed to identify factors at preschool age that are associated with persistent asthma at school age. This retrospective observational study included preschool children with asthma from 2015 to 2020 at a university hospital in Southern Thailand. In total, 189 eligible participants (70.9% boys; median age, 7.6 [6.7, 8.5] years) were included. Wheeze characteristics included early transient wheeze, persistent wheeze, and late-onset wheeze that accounted for 55%, 27.5%, and 19.5% of the patients, respectively. Approximately 20% of the participants had persistent asthma. Breastfeeding was a protective factor (odds ratio [OR] 0.4 [0.2, 0.9], p = 0.04). The modifiable risk factors were siblings living in the same household (OR 2.6 [1.1, 6.2], p = 0.02) and residence in an industrial area (OR 3.8 [1.4, 10.5], p = 0.009). Additionally, presence of allergic rhinitis was associated with an increased risk of persistent asthma at school age (OR 3.6 [1.6, 8.2], p = 0.002). Early therapeutic interventions targeting modifiable factors provide a window of opportunity to prevent persistent asthma at school age. MDPI 2022-12-24 /pmc/articles/PMC9856300/ /pubmed/36670584 http://dx.doi.org/10.3390/children10010033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sirianansopa, Kantisa
Ruangnapa, Kanokpan
Prasertsan, Pharsai
Saelim, Kantara
Anuntaseree, Wanaporn
Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title_full Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title_fullStr Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title_full_unstemmed Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title_short Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma
title_sort persistent asthma at school age: associated factors in preschool children with asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856300/
https://www.ncbi.nlm.nih.gov/pubmed/36670584
http://dx.doi.org/10.3390/children10010033
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