Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes

IMPORTANCE: Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused o...

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Detalles Bibliográficos
Autores principales: Jung, Sang-Hyuk, Kim, Hang-Rai, Chun, Min Young, Jang, Hyemin, Cho, Minyoung, Kim, Beomsu, Kim, Soyeon, Jeong, Jee Hyang, Yoon, Soo Jin, Park, Kyung Won, Kim, Eun-Joo, Yoon, Bora, Jang, Jae-Won, Kim, Yeshin, Hong, Jin Yong, Choi, Seong Hye, Noh, Young, Kim, Ko Woon, Kim, Si Eun, Lee, Jin San, Jung, Na-Yeon, Lee, Juyoun, Lee, Ae Young, Kim, Byeong C., Cho, Soo Hyun, Cho, Hanna, Kim, Jong Hun, Jung, Young Hee, Lee, Dong Young, Lee, Jae-Hong, Lee, Eek-Sung, Kim, Seung Joo, Moon, So Young, Son, Sang Joon, Hong, Chang Hyung, Bae, Jin-Sik, Lee, Sunghoon, Na, Duk L., Seo, Sang Won, Cruchaga, Carlos, Kim, Hee Jin, Won, Hong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856322/
https://www.ncbi.nlm.nih.gov/pubmed/36520433
http://dx.doi.org/10.1001/jamanetworkopen.2022.47162

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