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Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy

Objective: To determine the predictors and the long-term outcomes of patients with seizures following surgery for dysembryoplastic neuroepithelial tumors (DNTs); Methods: Clinical data were collected from medical records of consecutive patients of the Department of Neurosurgery of Sanbo Brain Hospit...

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Autores principales: Zhang, Huawei, Hu, Yue, Aihemaitiniyazi, Adilijiang, Li, Tiemin, Zhou, Jian, Guan, Yuguang, Qi, Xueling, Zhang, Xufei, Wang, Mengyang, Liu, Changqing, Luan, Guoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856460/
https://www.ncbi.nlm.nih.gov/pubmed/36672006
http://dx.doi.org/10.3390/brainsci13010024
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author Zhang, Huawei
Hu, Yue
Aihemaitiniyazi, Adilijiang
Li, Tiemin
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Zhang, Xufei
Wang, Mengyang
Liu, Changqing
Luan, Guoming
author_facet Zhang, Huawei
Hu, Yue
Aihemaitiniyazi, Adilijiang
Li, Tiemin
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Zhang, Xufei
Wang, Mengyang
Liu, Changqing
Luan, Guoming
author_sort Zhang, Huawei
collection PubMed
description Objective: To determine the predictors and the long-term outcomes of patients with seizures following surgery for dysembryoplastic neuroepithelial tumors (DNTs); Methods: Clinical data were collected from medical records of consecutive patients of the Department of Neurosurgery of Sanbo Brain Hospital of Capital Medical University with a pathological diagnosis of DNT and who underwent surgery from January 2008 to July 2021. All patients were followed up after surgery for at least one year. We estimated the cumulative rate of seizure recurrence-free and generated survival curves. A log-rank (Mantel–Cox) test and a Cox proportional hazard model were performed for univariate and multivariate analysis to analyze influential predictors; Results: 63 patients (33 males and 30 females) were included in this study. At the final follow-up, 49 patients (77.8%) were seizure-free. The cumulative rate of seizure recurrence-free was 82.5% (95% confidence interval (CI) 71.8–91.3%), 79.0% (95% CI 67.8–88.6%) and 76.5% (95% CI 64.8–87.0%) at 2, 5, and 10 years, respectively. The mean time for seizure recurrence-free was 6.892 ± 0.501 years (95% CI 5.91–7.87). Gross total removal of the tumor and a short epilepsy duration were significant predictors of seizure freedom. Younger age of seizure onset, bilateral interictal epileptiform discharges, and MRI type 3 tumors were risk factors for poor prognosis; Conclusions: A favorable long-term seizure outcome was observed for patients with DNT after surgical resection. Predictor analysis could effectively guide the clinical work and evaluate the prognosis of patients with DNT associated with epilepsy.
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spelling pubmed-98564602023-01-21 Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy Zhang, Huawei Hu, Yue Aihemaitiniyazi, Adilijiang Li, Tiemin Zhou, Jian Guan, Yuguang Qi, Xueling Zhang, Xufei Wang, Mengyang Liu, Changqing Luan, Guoming Brain Sci Article Objective: To determine the predictors and the long-term outcomes of patients with seizures following surgery for dysembryoplastic neuroepithelial tumors (DNTs); Methods: Clinical data were collected from medical records of consecutive patients of the Department of Neurosurgery of Sanbo Brain Hospital of Capital Medical University with a pathological diagnosis of DNT and who underwent surgery from January 2008 to July 2021. All patients were followed up after surgery for at least one year. We estimated the cumulative rate of seizure recurrence-free and generated survival curves. A log-rank (Mantel–Cox) test and a Cox proportional hazard model were performed for univariate and multivariate analysis to analyze influential predictors; Results: 63 patients (33 males and 30 females) were included in this study. At the final follow-up, 49 patients (77.8%) were seizure-free. The cumulative rate of seizure recurrence-free was 82.5% (95% confidence interval (CI) 71.8–91.3%), 79.0% (95% CI 67.8–88.6%) and 76.5% (95% CI 64.8–87.0%) at 2, 5, and 10 years, respectively. The mean time for seizure recurrence-free was 6.892 ± 0.501 years (95% CI 5.91–7.87). Gross total removal of the tumor and a short epilepsy duration were significant predictors of seizure freedom. Younger age of seizure onset, bilateral interictal epileptiform discharges, and MRI type 3 tumors were risk factors for poor prognosis; Conclusions: A favorable long-term seizure outcome was observed for patients with DNT after surgical resection. Predictor analysis could effectively guide the clinical work and evaluate the prognosis of patients with DNT associated with epilepsy. MDPI 2022-12-22 /pmc/articles/PMC9856460/ /pubmed/36672006 http://dx.doi.org/10.3390/brainsci13010024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Huawei
Hu, Yue
Aihemaitiniyazi, Adilijiang
Li, Tiemin
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Zhang, Xufei
Wang, Mengyang
Liu, Changqing
Luan, Guoming
Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title_full Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title_fullStr Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title_full_unstemmed Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title_short Long-Term Seizure Outcomes and Predictors in Patients with Dysembryoplastic Neuroepithelial Tumors Associated with Epilepsy
title_sort long-term seizure outcomes and predictors in patients with dysembryoplastic neuroepithelial tumors associated with epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856460/
https://www.ncbi.nlm.nih.gov/pubmed/36672006
http://dx.doi.org/10.3390/brainsci13010024
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