IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes

Ferroptosis has emerged as a cytotoxic T lymphocyte (CTL)-induced tumor cell death pathway. The regulation of tumor cell sensitivity to ferroptosis is incompletely understood. Here, we report that interferon regulatory factor 8 (IRF8) functions as a regulator of tumor cell intrinsic ferroptosis. Gen...

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Detalles Bibliográficos
Autores principales: Poschel, Dakota B., Kehinde-Ige, Mercy, Klement, John D., Yang, Dafeng, Merting, Alyssa D., Savage, Natasha M., Shi, Huidong, Liu, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856547/
https://www.ncbi.nlm.nih.gov/pubmed/36672246
http://dx.doi.org/10.3390/cells12020310

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