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The RUNX Family, a Novel Multifaceted Guardian of the Genome
The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for mu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856552/ https://www.ncbi.nlm.nih.gov/pubmed/36672189 http://dx.doi.org/10.3390/cells12020255 |
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author | Dutta, Bibek Osato, Motomi |
author_facet | Dutta, Bibek Osato, Motomi |
author_sort | Dutta, Bibek |
collection | PubMed |
description | The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for multiple biological functions such as embryonic development, stem cell behaviors, and oncogenesis. A significant number of studies in the past decades have delineated the involvement of RUNX proteins in DNA repair. Alterations in RUNX genes cause organ failure and predisposition to cancers, as seen in patients carrying mutations in the other well-established DNA repair genes. Herein, we review the currently existing findings and provide new insights into transcriptional and non-transcriptional multifaceted regulation of DNA repair by RUNX family proteins. |
format | Online Article Text |
id | pubmed-9856552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98565522023-01-21 The RUNX Family, a Novel Multifaceted Guardian of the Genome Dutta, Bibek Osato, Motomi Cells Review The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for multiple biological functions such as embryonic development, stem cell behaviors, and oncogenesis. A significant number of studies in the past decades have delineated the involvement of RUNX proteins in DNA repair. Alterations in RUNX genes cause organ failure and predisposition to cancers, as seen in patients carrying mutations in the other well-established DNA repair genes. Herein, we review the currently existing findings and provide new insights into transcriptional and non-transcriptional multifaceted regulation of DNA repair by RUNX family proteins. MDPI 2023-01-07 /pmc/articles/PMC9856552/ /pubmed/36672189 http://dx.doi.org/10.3390/cells12020255 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dutta, Bibek Osato, Motomi The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title | The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title_full | The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title_fullStr | The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title_full_unstemmed | The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title_short | The RUNX Family, a Novel Multifaceted Guardian of the Genome |
title_sort | runx family, a novel multifaceted guardian of the genome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856552/ https://www.ncbi.nlm.nih.gov/pubmed/36672189 http://dx.doi.org/10.3390/cells12020255 |
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