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The RUNX Family, a Novel Multifaceted Guardian of the Genome

The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for mu...

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Detalles Bibliográficos
Autores principales: Dutta, Bibek, Osato, Motomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856552/
https://www.ncbi.nlm.nih.gov/pubmed/36672189
http://dx.doi.org/10.3390/cells12020255
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author Dutta, Bibek
Osato, Motomi
author_facet Dutta, Bibek
Osato, Motomi
author_sort Dutta, Bibek
collection PubMed
description The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for multiple biological functions such as embryonic development, stem cell behaviors, and oncogenesis. A significant number of studies in the past decades have delineated the involvement of RUNX proteins in DNA repair. Alterations in RUNX genes cause organ failure and predisposition to cancers, as seen in patients carrying mutations in the other well-established DNA repair genes. Herein, we review the currently existing findings and provide new insights into transcriptional and non-transcriptional multifaceted regulation of DNA repair by RUNX family proteins.
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spelling pubmed-98565522023-01-21 The RUNX Family, a Novel Multifaceted Guardian of the Genome Dutta, Bibek Osato, Motomi Cells Review The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for multiple biological functions such as embryonic development, stem cell behaviors, and oncogenesis. A significant number of studies in the past decades have delineated the involvement of RUNX proteins in DNA repair. Alterations in RUNX genes cause organ failure and predisposition to cancers, as seen in patients carrying mutations in the other well-established DNA repair genes. Herein, we review the currently existing findings and provide new insights into transcriptional and non-transcriptional multifaceted regulation of DNA repair by RUNX family proteins. MDPI 2023-01-07 /pmc/articles/PMC9856552/ /pubmed/36672189 http://dx.doi.org/10.3390/cells12020255 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dutta, Bibek
Osato, Motomi
The RUNX Family, a Novel Multifaceted Guardian of the Genome
title The RUNX Family, a Novel Multifaceted Guardian of the Genome
title_full The RUNX Family, a Novel Multifaceted Guardian of the Genome
title_fullStr The RUNX Family, a Novel Multifaceted Guardian of the Genome
title_full_unstemmed The RUNX Family, a Novel Multifaceted Guardian of the Genome
title_short The RUNX Family, a Novel Multifaceted Guardian of the Genome
title_sort runx family, a novel multifaceted guardian of the genome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856552/
https://www.ncbi.nlm.nih.gov/pubmed/36672189
http://dx.doi.org/10.3390/cells12020255
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