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Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study

The aim of the present study was to examine the neurobiological correlates of the two negative symptom domains of schizophrenia, the Motivational Deficit domain (including avolition, anhedonia, and asociality) and the Expressive Deficit domain (including blunted affect and alogia), focusing on brain...

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Autores principales: Giordano, Giulia Maria, Pezzella, Pasquale, Giuliani, Luigi, Fazio, Leonardo, Mucci, Armida, Perrottelli, Andrea, Blasi, Giuseppe, Amore, Mario, Rocca, Paola, Rossi, Alessandro, Bertolino, Alessandro, Galderisi, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856573/
https://www.ncbi.nlm.nih.gov/pubmed/36672064
http://dx.doi.org/10.3390/brainsci13010083
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author Giordano, Giulia Maria
Pezzella, Pasquale
Giuliani, Luigi
Fazio, Leonardo
Mucci, Armida
Perrottelli, Andrea
Blasi, Giuseppe
Amore, Mario
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Galderisi, Silvana
author_facet Giordano, Giulia Maria
Pezzella, Pasquale
Giuliani, Luigi
Fazio, Leonardo
Mucci, Armida
Perrottelli, Andrea
Blasi, Giuseppe
Amore, Mario
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Galderisi, Silvana
author_sort Giordano, Giulia Maria
collection PubMed
description The aim of the present study was to examine the neurobiological correlates of the two negative symptom domains of schizophrenia, the Motivational Deficit domain (including avolition, anhedonia, and asociality) and the Expressive Deficit domain (including blunted affect and alogia), focusing on brain areas that are most commonly found to be associated with negative symptoms in previous literature. Resting-state (rs) fMRI data were analyzed in 62 subjects affected by schizophrenia (SZs) and 46 healthy controls (HCs). The SZs, compared to the HCs, showed higher rs brain activity in the right inferior parietal lobule and the right temporoparietal junction, and lower rs brain activity in the right dorsolateral prefrontal cortex, the bilateral anterior dorsal cingulate cortex, and the ventral and dorsal caudate. Furthermore, in the SZs, the rs brain activity in the left orbitofrontal cortex correlated with negative symptoms (r = −0.436, p = 0.006), in particular with the Motivational Deficit domain (r = −0.424, p = 0.002), even after controlling for confounding factors. The left ventral caudate correlated with negative symptoms (r = −0.407, p = 0.003), especially with the Expressive Deficit domain (r = −0.401, p = 0.003); however, these results seemed to be affected by confounding factors. In line with the literature, our results demonstrated that the two negative symptom domains might be underpinned by different neurobiological mechanisms.
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spelling pubmed-98565732023-01-21 Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study Giordano, Giulia Maria Pezzella, Pasquale Giuliani, Luigi Fazio, Leonardo Mucci, Armida Perrottelli, Andrea Blasi, Giuseppe Amore, Mario Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Galderisi, Silvana Brain Sci Article The aim of the present study was to examine the neurobiological correlates of the two negative symptom domains of schizophrenia, the Motivational Deficit domain (including avolition, anhedonia, and asociality) and the Expressive Deficit domain (including blunted affect and alogia), focusing on brain areas that are most commonly found to be associated with negative symptoms in previous literature. Resting-state (rs) fMRI data were analyzed in 62 subjects affected by schizophrenia (SZs) and 46 healthy controls (HCs). The SZs, compared to the HCs, showed higher rs brain activity in the right inferior parietal lobule and the right temporoparietal junction, and lower rs brain activity in the right dorsolateral prefrontal cortex, the bilateral anterior dorsal cingulate cortex, and the ventral and dorsal caudate. Furthermore, in the SZs, the rs brain activity in the left orbitofrontal cortex correlated with negative symptoms (r = −0.436, p = 0.006), in particular with the Motivational Deficit domain (r = −0.424, p = 0.002), even after controlling for confounding factors. The left ventral caudate correlated with negative symptoms (r = −0.407, p = 0.003), especially with the Expressive Deficit domain (r = −0.401, p = 0.003); however, these results seemed to be affected by confounding factors. In line with the literature, our results demonstrated that the two negative symptom domains might be underpinned by different neurobiological mechanisms. MDPI 2023-01-01 /pmc/articles/PMC9856573/ /pubmed/36672064 http://dx.doi.org/10.3390/brainsci13010083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Giordano, Giulia Maria
Pezzella, Pasquale
Giuliani, Luigi
Fazio, Leonardo
Mucci, Armida
Perrottelli, Andrea
Blasi, Giuseppe
Amore, Mario
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Galderisi, Silvana
Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title_full Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title_fullStr Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title_full_unstemmed Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title_short Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
title_sort resting-state brain activity dysfunctions in schizophrenia and their associations with negative symptom domains: an fmri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856573/
https://www.ncbi.nlm.nih.gov/pubmed/36672064
http://dx.doi.org/10.3390/brainsci13010083
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