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Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature

The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocom...

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Autores principales: Mamilos, Andreas, Winter, Lina, Schmitt, Volker H., Barsch, Friedrich, Grevenstein, David, Wagner, Willi, Babel, Maximilian, Keller, Karsten, Schmitt, Christine, Gürtler, Florian, Schreml, Stephan, Niedermair, Tanja, Rupp, Markus, Alt, Volker, Brochhausen, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856654/
https://www.ncbi.nlm.nih.gov/pubmed/36672212
http://dx.doi.org/10.3390/cells12020276
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author Mamilos, Andreas
Winter, Lina
Schmitt, Volker H.
Barsch, Friedrich
Grevenstein, David
Wagner, Willi
Babel, Maximilian
Keller, Karsten
Schmitt, Christine
Gürtler, Florian
Schreml, Stephan
Niedermair, Tanja
Rupp, Markus
Alt, Volker
Brochhausen, Christoph
author_facet Mamilos, Andreas
Winter, Lina
Schmitt, Volker H.
Barsch, Friedrich
Grevenstein, David
Wagner, Willi
Babel, Maximilian
Keller, Karsten
Schmitt, Christine
Gürtler, Florian
Schreml, Stephan
Niedermair, Tanja
Rupp, Markus
Alt, Volker
Brochhausen, Christoph
author_sort Mamilos, Andreas
collection PubMed
description The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocompatibility and degradation of implanted biomaterials. Furthermore, a better understanding of the functionality of macrophages opens perspectives for potential guidance and modulation to turn inflammation into regeneration. Such knowledge may help to improve not only the biocompatibility of scaffold materials but also the integration, maturation, and preservation of scaffold-cell constructs or induce regeneration. Nowadays, macrophages are classified into two subpopulations, the classically activated macrophages (M1 macrophages) with pro-inflammatory properties and the alternatively activated macrophages (M2 macrophages) with anti-inflammatory properties. The present narrative review gives an overview of the different functions of macrophages and summarizes the recent state of knowledge regarding different types of macrophages and their functions, with special emphasis on tissue engineering and tissue regeneration.
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spelling pubmed-98566542023-01-21 Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature Mamilos, Andreas Winter, Lina Schmitt, Volker H. Barsch, Friedrich Grevenstein, David Wagner, Willi Babel, Maximilian Keller, Karsten Schmitt, Christine Gürtler, Florian Schreml, Stephan Niedermair, Tanja Rupp, Markus Alt, Volker Brochhausen, Christoph Cells Review The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocompatibility and degradation of implanted biomaterials. Furthermore, a better understanding of the functionality of macrophages opens perspectives for potential guidance and modulation to turn inflammation into regeneration. Such knowledge may help to improve not only the biocompatibility of scaffold materials but also the integration, maturation, and preservation of scaffold-cell constructs or induce regeneration. Nowadays, macrophages are classified into two subpopulations, the classically activated macrophages (M1 macrophages) with pro-inflammatory properties and the alternatively activated macrophages (M2 macrophages) with anti-inflammatory properties. The present narrative review gives an overview of the different functions of macrophages and summarizes the recent state of knowledge regarding different types of macrophages and their functions, with special emphasis on tissue engineering and tissue regeneration. MDPI 2023-01-11 /pmc/articles/PMC9856654/ /pubmed/36672212 http://dx.doi.org/10.3390/cells12020276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mamilos, Andreas
Winter, Lina
Schmitt, Volker H.
Barsch, Friedrich
Grevenstein, David
Wagner, Willi
Babel, Maximilian
Keller, Karsten
Schmitt, Christine
Gürtler, Florian
Schreml, Stephan
Niedermair, Tanja
Rupp, Markus
Alt, Volker
Brochhausen, Christoph
Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title_full Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title_fullStr Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title_full_unstemmed Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title_short Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
title_sort macrophages: from simple phagocyte to an integrative regulatory cell for inflammation and tissue regeneration—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856654/
https://www.ncbi.nlm.nih.gov/pubmed/36672212
http://dx.doi.org/10.3390/cells12020276
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