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Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocom...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856654/ https://www.ncbi.nlm.nih.gov/pubmed/36672212 http://dx.doi.org/10.3390/cells12020276 |
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author | Mamilos, Andreas Winter, Lina Schmitt, Volker H. Barsch, Friedrich Grevenstein, David Wagner, Willi Babel, Maximilian Keller, Karsten Schmitt, Christine Gürtler, Florian Schreml, Stephan Niedermair, Tanja Rupp, Markus Alt, Volker Brochhausen, Christoph |
author_facet | Mamilos, Andreas Winter, Lina Schmitt, Volker H. Barsch, Friedrich Grevenstein, David Wagner, Willi Babel, Maximilian Keller, Karsten Schmitt, Christine Gürtler, Florian Schreml, Stephan Niedermair, Tanja Rupp, Markus Alt, Volker Brochhausen, Christoph |
author_sort | Mamilos, Andreas |
collection | PubMed |
description | The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocompatibility and degradation of implanted biomaterials. Furthermore, a better understanding of the functionality of macrophages opens perspectives for potential guidance and modulation to turn inflammation into regeneration. Such knowledge may help to improve not only the biocompatibility of scaffold materials but also the integration, maturation, and preservation of scaffold-cell constructs or induce regeneration. Nowadays, macrophages are classified into two subpopulations, the classically activated macrophages (M1 macrophages) with pro-inflammatory properties and the alternatively activated macrophages (M2 macrophages) with anti-inflammatory properties. The present narrative review gives an overview of the different functions of macrophages and summarizes the recent state of knowledge regarding different types of macrophages and their functions, with special emphasis on tissue engineering and tissue regeneration. |
format | Online Article Text |
id | pubmed-9856654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98566542023-01-21 Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature Mamilos, Andreas Winter, Lina Schmitt, Volker H. Barsch, Friedrich Grevenstein, David Wagner, Willi Babel, Maximilian Keller, Karsten Schmitt, Christine Gürtler, Florian Schreml, Stephan Niedermair, Tanja Rupp, Markus Alt, Volker Brochhausen, Christoph Cells Review The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocompatibility and degradation of implanted biomaterials. Furthermore, a better understanding of the functionality of macrophages opens perspectives for potential guidance and modulation to turn inflammation into regeneration. Such knowledge may help to improve not only the biocompatibility of scaffold materials but also the integration, maturation, and preservation of scaffold-cell constructs or induce regeneration. Nowadays, macrophages are classified into two subpopulations, the classically activated macrophages (M1 macrophages) with pro-inflammatory properties and the alternatively activated macrophages (M2 macrophages) with anti-inflammatory properties. The present narrative review gives an overview of the different functions of macrophages and summarizes the recent state of knowledge regarding different types of macrophages and their functions, with special emphasis on tissue engineering and tissue regeneration. MDPI 2023-01-11 /pmc/articles/PMC9856654/ /pubmed/36672212 http://dx.doi.org/10.3390/cells12020276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mamilos, Andreas Winter, Lina Schmitt, Volker H. Barsch, Friedrich Grevenstein, David Wagner, Willi Babel, Maximilian Keller, Karsten Schmitt, Christine Gürtler, Florian Schreml, Stephan Niedermair, Tanja Rupp, Markus Alt, Volker Brochhausen, Christoph Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title | Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title_full | Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title_fullStr | Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title_full_unstemmed | Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title_short | Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature |
title_sort | macrophages: from simple phagocyte to an integrative regulatory cell for inflammation and tissue regeneration—a review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856654/ https://www.ncbi.nlm.nih.gov/pubmed/36672212 http://dx.doi.org/10.3390/cells12020276 |
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