SGC-CAMKK2-1: A Chemical Probe for CAMKK2

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this ki...

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Autores principales: Wells, Carrow, Liang, Yi, Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O’Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M., Stork, Brittany, Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Mukherjee, Debarati, Racioppi, Luigi, Means, Anthony R., York, Brian, McDonnell, Donald P., Scott, John W., Frigo, Daniel E., Drewry, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856672/
https://www.ncbi.nlm.nih.gov/pubmed/36672221
http://dx.doi.org/10.3390/cells12020287
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author Wells, Carrow
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Gileadi, Opher
Gileadi, Carina
Couñago, Rafael M.
Stork, Brittany
Langendorf, Christopher G.
Nay, Kevin
Oakhill, Jonathan S.
Mukherjee, Debarati
Racioppi, Luigi
Means, Anthony R.
York, Brian
McDonnell, Donald P.
Scott, John W.
Frigo, Daniel E.
Drewry, David H.
author_facet Wells, Carrow
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Gileadi, Opher
Gileadi, Carina
Couñago, Rafael M.
Stork, Brittany
Langendorf, Christopher G.
Nay, Kevin
Oakhill, Jonathan S.
Mukherjee, Debarati
Racioppi, Luigi
Means, Anthony R.
York, Brian
McDonnell, Donald P.
Scott, John W.
Frigo, Daniel E.
Drewry, David H.
author_sort Wells, Carrow
collection PubMed
description The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.
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spelling pubmed-98566722023-01-21 SGC-CAMKK2-1: A Chemical Probe for CAMKK2 Wells, Carrow Liang, Yi Pulliam, Thomas L. Lin, Chenchu Awad, Dominik Eduful, Benjamin O’Byrne, Sean Hossain, Mohammad Anwar Catta-Preta, Carolina Moura Costa Ramos, Priscila Zonzini Gileadi, Opher Gileadi, Carina Couñago, Rafael M. Stork, Brittany Langendorf, Christopher G. Nay, Kevin Oakhill, Jonathan S. Mukherjee, Debarati Racioppi, Luigi Means, Anthony R. York, Brian McDonnell, Donald P. Scott, John W. Frigo, Daniel E. Drewry, David H. Cells Article The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2. MDPI 2023-01-11 /pmc/articles/PMC9856672/ /pubmed/36672221 http://dx.doi.org/10.3390/cells12020287 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wells, Carrow
Liang, Yi
Pulliam, Thomas L.
Lin, Chenchu
Awad, Dominik
Eduful, Benjamin
O’Byrne, Sean
Hossain, Mohammad Anwar
Catta-Preta, Carolina Moura Costa
Ramos, Priscila Zonzini
Gileadi, Opher
Gileadi, Carina
Couñago, Rafael M.
Stork, Brittany
Langendorf, Christopher G.
Nay, Kevin
Oakhill, Jonathan S.
Mukherjee, Debarati
Racioppi, Luigi
Means, Anthony R.
York, Brian
McDonnell, Donald P.
Scott, John W.
Frigo, Daniel E.
Drewry, David H.
SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title_full SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title_fullStr SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title_full_unstemmed SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title_short SGC-CAMKK2-1: A Chemical Probe for CAMKK2
title_sort sgc-camkk2-1: a chemical probe for camkk2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856672/
https://www.ncbi.nlm.nih.gov/pubmed/36672221
http://dx.doi.org/10.3390/cells12020287
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