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iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release

Multiple system atrophy of the parkinsonian type (MSA-P) is a rare, fatal neurodegenerative disease with sporadic onset. It is still unknown if MSA-P is a primary oligodendropathy or caused by neuronal pathophysiology leading to severe, α-synuclein-associated neurodegeneration, mainly in the striatu...

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Detalles Bibliográficos
Autores principales:	Henkel, Lisa M., Kankowski, Svenja, Moellenkamp, Thiemo M., Smandzich, Nadine J., Schwarz, Sigrid, Di Fonzo, Alessio, Göhring, Gudrun, Höglinger, Günter, Wegner, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856678/ https://www.ncbi.nlm.nih.gov/pubmed/36672158 http://dx.doi.org/10.3390/cells12020223

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