Cargando…
Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856690/ https://www.ncbi.nlm.nih.gov/pubmed/36672187 http://dx.doi.org/10.3390/cells12020252 |
_version_ | 1784873694982569984 |
---|---|
author | Mhalhel, Kamel Sicari, Mirea Pansera, Lidia Chen, Jincan Levanti, Maria Diotel, Nicolas Rastegar, Sepand Germanà, Antonino Montalbano, Giuseppe |
author_facet | Mhalhel, Kamel Sicari, Mirea Pansera, Lidia Chen, Jincan Levanti, Maria Diotel, Nicolas Rastegar, Sepand Germanà, Antonino Montalbano, Giuseppe |
author_sort | Mhalhel, Kamel |
collection | PubMed |
description | Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Moreover, flavonoids are known to impact the biological processes involved in developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, and mitochondrial dysfunction. Thus, several flavonoids could be used as adjuvants to prevent and counteract neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Zebrafish is an interesting model organism that can offer new opportunities to study the beneficial effects of flavonoids on neurodegenerative diseases. Indeed, the high genome homology of 70% to humans, the brain organization largely similar to the human brain as well as the similar neuroanatomical and neurochemical processes, and the high neurogenic activity maintained in the adult brain makes zebrafish a valuable model for the study of human neurodegenerative diseases and deciphering the impact of flavonoids on those disorders. |
format | Online Article Text |
id | pubmed-9856690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98566902023-01-21 Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders Mhalhel, Kamel Sicari, Mirea Pansera, Lidia Chen, Jincan Levanti, Maria Diotel, Nicolas Rastegar, Sepand Germanà, Antonino Montalbano, Giuseppe Cells Review Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Moreover, flavonoids are known to impact the biological processes involved in developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, and mitochondrial dysfunction. Thus, several flavonoids could be used as adjuvants to prevent and counteract neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Zebrafish is an interesting model organism that can offer new opportunities to study the beneficial effects of flavonoids on neurodegenerative diseases. Indeed, the high genome homology of 70% to humans, the brain organization largely similar to the human brain as well as the similar neuroanatomical and neurochemical processes, and the high neurogenic activity maintained in the adult brain makes zebrafish a valuable model for the study of human neurodegenerative diseases and deciphering the impact of flavonoids on those disorders. MDPI 2023-01-07 /pmc/articles/PMC9856690/ /pubmed/36672187 http://dx.doi.org/10.3390/cells12020252 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mhalhel, Kamel Sicari, Mirea Pansera, Lidia Chen, Jincan Levanti, Maria Diotel, Nicolas Rastegar, Sepand Germanà, Antonino Montalbano, Giuseppe Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title | Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title_full | Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title_fullStr | Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title_full_unstemmed | Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title_short | Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders |
title_sort | zebrafish: a model deciphering the impact of flavonoids on neurodegenerative disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856690/ https://www.ncbi.nlm.nih.gov/pubmed/36672187 http://dx.doi.org/10.3390/cells12020252 |
work_keys_str_mv | AT mhalhelkamel zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT sicarimirea zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT panseralidia zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT chenjincan zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT levantimaria zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT diotelnicolas zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT rastegarsepand zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT germanaantonino zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders AT montalbanogiuseppe zebrafishamodeldecipheringtheimpactofflavonoidsonneurodegenerativedisorders |