The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model

Dravet syndrome (DRVT) is a rare form of neurodevelopmental disorder with a high risk of sudden unexpected death in epilepsy (SUDEP), caused mainly (>80% cases) by mutations in the SCN1A gene, coding the Nav1.1 protein (alfa-subunit of voltage-sensitive sodium channel). Mutations in SCN1A are lin...

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Detalles Bibliográficos
Autores principales: Zayat, Valery, Kuczynska, Zuzanna, Liput, Michal, Metin, Erkan, Rzonca-Niewczas, Sylwia, Smyk, Marta, Mazurczak, Tomasz, Goszczanska-Ciuchta, Alicja, Leszczynski, Pawel, Hoffman-Zacharska, Dorota, Buzanska, Leonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856691/
https://www.ncbi.nlm.nih.gov/pubmed/36672274
http://dx.doi.org/10.3390/cells12020339

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