Engineering mighty microglia

Defective microglial responses underlie many neurological disorders. Recent efforts to swap out dysfunctional microglia with optimized replacements have been derailed by safety issues and transplantation inefficiencies. In this issue, Chadarevian et al. (2023. J. Exp. Med. https://doi.org/10.1084/je...

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Detalles Bibliográficos
Autores principales: Walsh, Adeline E., Lukens, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856716/
https://www.ncbi.nlm.nih.gov/pubmed/36648421
http://dx.doi.org/10.1084/jem.20222070
Descripción
Sumario:Defective microglial responses underlie many neurological disorders. Recent efforts to swap out dysfunctional microglia with optimized replacements have been derailed by safety issues and transplantation inefficiencies. In this issue, Chadarevian et al. (2023. J. Exp. Med. https://doi.org/10.1084/jem.20220857) designed a novel strategy that enables improved engraftment of human microglia.

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