Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?

The molecular mechanism of sperm–egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane f...

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Detalles Bibliográficos
Autores principales: Bianchi, Enrica, Wright, Gavin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856796/
https://www.ncbi.nlm.nih.gov/pubmed/36656648
http://dx.doi.org/10.1083/jcb.202301035
Descripción
Sumario:The molecular mechanism of sperm–egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane fusion in cultured cells.

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