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Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching
Prolactinomas have been reported to impair cognition in broad aspects. However, few studies investigated the influence of prolactinomas on cognitive flexibility never mentioning the underlying neural and electrophysiological mechanism. We recorded scalp electroencephalography (EEG) in a colour-shape...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856801/ https://www.ncbi.nlm.nih.gov/pubmed/36672063 http://dx.doi.org/10.3390/brainsci13010082 |
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author | Cao, Chenglong Wen, Wen Chen, Aobo Wang, Shuochen Xu, Guozheng Niu, Chaoshi Song, Jian |
author_facet | Cao, Chenglong Wen, Wen Chen, Aobo Wang, Shuochen Xu, Guozheng Niu, Chaoshi Song, Jian |
author_sort | Cao, Chenglong |
collection | PubMed |
description | Prolactinomas have been reported to impair cognition in broad aspects. However, few studies investigated the influence of prolactinomas on cognitive flexibility never mentioning the underlying neural and electrophysiological mechanism. We recorded scalp electroencephalography (EEG) in a colour-shape switching task. Patients with prolactinomas showed longer reaction time in switch trials and larger switch costs relative to healthy controls (HCs). Compared to HCs who showed stronger frontal theta activity in switch trials, the generally weak frontal theta activity in patients implied that they could not afford the executive control to configure task sets. Meanwhile, machine-learning based classification revealed that patients manifested non-selective brain patterns in response to different task types (colour vs. shape task) and different task states (switch vs. repeat state), which collectively suggested the cognitive dysfunction in preparation for a changing environment. Compared to HCs who showed stronger frontoparietal synchronization in switch trials, this enhanced frontoparietal connectivity was disrupted among patients with severe prolactinomas. This finding implicated greater hyperprolactinemia was linked to a larger decrease in cognitive performance. Taken together, the present study highlighted frontal theta power, and frontoparietal connectivity at theta band as the electrophysiological markers of the impaired cognitive flexibility and task control in patients with prolactinomas. |
format | Online Article Text |
id | pubmed-9856801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98568012023-01-21 Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching Cao, Chenglong Wen, Wen Chen, Aobo Wang, Shuochen Xu, Guozheng Niu, Chaoshi Song, Jian Brain Sci Article Prolactinomas have been reported to impair cognition in broad aspects. However, few studies investigated the influence of prolactinomas on cognitive flexibility never mentioning the underlying neural and electrophysiological mechanism. We recorded scalp electroencephalography (EEG) in a colour-shape switching task. Patients with prolactinomas showed longer reaction time in switch trials and larger switch costs relative to healthy controls (HCs). Compared to HCs who showed stronger frontal theta activity in switch trials, the generally weak frontal theta activity in patients implied that they could not afford the executive control to configure task sets. Meanwhile, machine-learning based classification revealed that patients manifested non-selective brain patterns in response to different task types (colour vs. shape task) and different task states (switch vs. repeat state), which collectively suggested the cognitive dysfunction in preparation for a changing environment. Compared to HCs who showed stronger frontoparietal synchronization in switch trials, this enhanced frontoparietal connectivity was disrupted among patients with severe prolactinomas. This finding implicated greater hyperprolactinemia was linked to a larger decrease in cognitive performance. Taken together, the present study highlighted frontal theta power, and frontoparietal connectivity at theta band as the electrophysiological markers of the impaired cognitive flexibility and task control in patients with prolactinomas. MDPI 2023-01-01 /pmc/articles/PMC9856801/ /pubmed/36672063 http://dx.doi.org/10.3390/brainsci13010082 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cao, Chenglong Wen, Wen Chen, Aobo Wang, Shuochen Xu, Guozheng Niu, Chaoshi Song, Jian Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title | Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title_full | Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title_fullStr | Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title_full_unstemmed | Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title_short | Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching |
title_sort | neuropsychological alterations of prolactinomas’ cognitive flexibility in task switching |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856801/ https://www.ncbi.nlm.nih.gov/pubmed/36672063 http://dx.doi.org/10.3390/brainsci13010082 |
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