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Early Life Stress (ELS) Effects on Fetal and Adult Bone Development

Early life stress (ELS) refers to harmful environmental events (i.e., poor maternal health, metabolic restraint, childhood trauma) occurring during the prenatal and/or postnatal period, which may cause the ‘epigenetic corruption’ of cellular and molecular signaling of mental and physical development...

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Autores principales: Pappalardo, Xena Giada, Testa, Gianluca, Pellitteri, Rosalia, Dell’Albani, Paola, Rodolico, Margherita, Pavone, Vito, Parano, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856960/
https://www.ncbi.nlm.nih.gov/pubmed/36670652
http://dx.doi.org/10.3390/children10010102
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author Pappalardo, Xena Giada
Testa, Gianluca
Pellitteri, Rosalia
Dell’Albani, Paola
Rodolico, Margherita
Pavone, Vito
Parano, Enrico
author_facet Pappalardo, Xena Giada
Testa, Gianluca
Pellitteri, Rosalia
Dell’Albani, Paola
Rodolico, Margherita
Pavone, Vito
Parano, Enrico
author_sort Pappalardo, Xena Giada
collection PubMed
description Early life stress (ELS) refers to harmful environmental events (i.e., poor maternal health, metabolic restraint, childhood trauma) occurring during the prenatal and/or postnatal period, which may cause the ‘epigenetic corruption’ of cellular and molecular signaling of mental and physical development. While the impact of ELS in a wide range of human diseases has been confirmed, the ELS susceptibility to bone diseases has been poorly explored. In this review, to understand the potential mediating pathways of ELS in bone diseases, PRISMA criteria were used to analyze different stress protocols in mammal models and the effects elicited in dams and their progeny. Data collected, despite the methodological heterogeneity, show that ELS interferes with fetal bone formation, also revealing that the stress type and affected developmental phase may influence the variety and severity of bone anomalies. Interestingly, these findings highlight the maternal and fetal ability to buffer stress, establishing a new role for the placenta in minimizing ELS perturbations. The functional link between ELS and bone impairments will boost future investigations on maternal stress transmission to the fetus and, parallelly, help the assessment of catch-up mechanisms of skeleton adaptations from the cascading ELS effects.
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spelling pubmed-98569602023-01-21 Early Life Stress (ELS) Effects on Fetal and Adult Bone Development Pappalardo, Xena Giada Testa, Gianluca Pellitteri, Rosalia Dell’Albani, Paola Rodolico, Margherita Pavone, Vito Parano, Enrico Children (Basel) Review Early life stress (ELS) refers to harmful environmental events (i.e., poor maternal health, metabolic restraint, childhood trauma) occurring during the prenatal and/or postnatal period, which may cause the ‘epigenetic corruption’ of cellular and molecular signaling of mental and physical development. While the impact of ELS in a wide range of human diseases has been confirmed, the ELS susceptibility to bone diseases has been poorly explored. In this review, to understand the potential mediating pathways of ELS in bone diseases, PRISMA criteria were used to analyze different stress protocols in mammal models and the effects elicited in dams and their progeny. Data collected, despite the methodological heterogeneity, show that ELS interferes with fetal bone formation, also revealing that the stress type and affected developmental phase may influence the variety and severity of bone anomalies. Interestingly, these findings highlight the maternal and fetal ability to buffer stress, establishing a new role for the placenta in minimizing ELS perturbations. The functional link between ELS and bone impairments will boost future investigations on maternal stress transmission to the fetus and, parallelly, help the assessment of catch-up mechanisms of skeleton adaptations from the cascading ELS effects. MDPI 2023-01-03 /pmc/articles/PMC9856960/ /pubmed/36670652 http://dx.doi.org/10.3390/children10010102 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pappalardo, Xena Giada
Testa, Gianluca
Pellitteri, Rosalia
Dell’Albani, Paola
Rodolico, Margherita
Pavone, Vito
Parano, Enrico
Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title_full Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title_fullStr Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title_full_unstemmed Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title_short Early Life Stress (ELS) Effects on Fetal and Adult Bone Development
title_sort early life stress (els) effects on fetal and adult bone development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856960/
https://www.ncbi.nlm.nih.gov/pubmed/36670652
http://dx.doi.org/10.3390/children10010102
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