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Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database
Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolep...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856970/ https://www.ncbi.nlm.nih.gov/pubmed/36672025 http://dx.doi.org/10.3390/brainsci13010043 |
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author | Feketeová, Eva Dragašek, Jozef Klobučníková, Katarína Ďurdík, Peter Čarnakovič, Simona Slavkovská, Miriam Chylová, Martina |
author_facet | Feketeová, Eva Dragašek, Jozef Klobučníková, Katarína Ďurdík, Peter Čarnakovič, Simona Slavkovská, Miriam Chylová, Martina |
author_sort | Feketeová, Eva |
collection | PubMed |
description | Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical characteristics of these cases, and to look for narcoleptic and psychotic symptoms during re-evaluation years later. We identified three (4%) cases diagnosed with a psychotic episode in the course of NT1. They were diagnosed with NT1 by age ≤18 years. In the re-evaluation (mean follow-up 9.8 years), we identified one case with a dual diagnosis of NT1 and schizophrenia; two cases were diagnosed with a solitary psychotic episode in the course of NT1. NT1 patients diagnosed in the age ≤18 years are at higher risk of psychotic episode, and this may be related to higher vulnerability during the ongoing neurodevelopmental period. Comorbid schizophrenia with NT1 in the Slovakian Narcolepsy Database was within the prevalence expected in the general population. The solitary psychotic episode in the course of NT1 did not reduce the possibility of subsequent symptomatic treatment afterwards. |
format | Online Article Text |
id | pubmed-9856970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98569702023-01-21 Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database Feketeová, Eva Dragašek, Jozef Klobučníková, Katarína Ďurdík, Peter Čarnakovič, Simona Slavkovská, Miriam Chylová, Martina Brain Sci Article Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical characteristics of these cases, and to look for narcoleptic and psychotic symptoms during re-evaluation years later. We identified three (4%) cases diagnosed with a psychotic episode in the course of NT1. They were diagnosed with NT1 by age ≤18 years. In the re-evaluation (mean follow-up 9.8 years), we identified one case with a dual diagnosis of NT1 and schizophrenia; two cases were diagnosed with a solitary psychotic episode in the course of NT1. NT1 patients diagnosed in the age ≤18 years are at higher risk of psychotic episode, and this may be related to higher vulnerability during the ongoing neurodevelopmental period. Comorbid schizophrenia with NT1 in the Slovakian Narcolepsy Database was within the prevalence expected in the general population. The solitary psychotic episode in the course of NT1 did not reduce the possibility of subsequent symptomatic treatment afterwards. MDPI 2022-12-24 /pmc/articles/PMC9856970/ /pubmed/36672025 http://dx.doi.org/10.3390/brainsci13010043 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Feketeová, Eva Dragašek, Jozef Klobučníková, Katarína Ďurdík, Peter Čarnakovič, Simona Slavkovská, Miriam Chylová, Martina Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title_full | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title_fullStr | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title_full_unstemmed | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title_short | Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database |
title_sort | psychotic episode and schizophrenia in slovakian narcolepsy database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856970/ https://www.ncbi.nlm.nih.gov/pubmed/36672025 http://dx.doi.org/10.3390/brainsci13010043 |
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