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The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study

BACKGROUND: The complex wound healing process involves activating and synchronizing intracellular, intercellular, and extracellular components. Adipose tissue is attracting attention to promote wound healing. Within subcutaneous adipose tissue, stromal vascular cells and their subsets release growth...

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Autores principales: Abbasi, Kamyar, Tavakolizadeh, Sara, Hadi, Alireza, Hosseini, Maryam, Soufdoost, Reza Sayyad, Heboyan, Artak, Alam, Mostafa, Fani‐Hanifeh, Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856998/
https://www.ncbi.nlm.nih.gov/pubmed/36571812
http://dx.doi.org/10.1002/vms3.1059
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author Abbasi, Kamyar
Tavakolizadeh, Sara
Hadi, Alireza
Hosseini, Maryam
Soufdoost, Reza Sayyad
Heboyan, Artak
Alam, Mostafa
Fani‐Hanifeh, Sadaf
author_facet Abbasi, Kamyar
Tavakolizadeh, Sara
Hadi, Alireza
Hosseini, Maryam
Soufdoost, Reza Sayyad
Heboyan, Artak
Alam, Mostafa
Fani‐Hanifeh, Sadaf
author_sort Abbasi, Kamyar
collection PubMed
description BACKGROUND: The complex wound healing process involves activating and synchronizing intracellular, intercellular, and extracellular components. Adipose tissue is attracting attention to promote wound healing. Within subcutaneous adipose tissue, stromal vascular cells and their subsets release growth factors and cytokines critical for neovascularization and wound repair. OBJECTIVES: This study evaluated human placental collagen/adipose‐derived stem cells (ADSCs) hydrogel for wound healing in rats. METHODS: In this study, ADSCs were harvested, cultured, and mixed with placental collagen. Twelve rats were used, and their backs were excised three times each. Group one received collagen/ADSCs, group two collagen, and group three non‐filled (control) excisions. The healing processes were assessed by histological analysis, taking photographs, and calculating the percentage of wound contraction in mentioned times. RESULTS: Histopathological analysis revealed that the content of fibroblasts, follicles of the hair, and angiogenesis in group one was significantly more than in other groups. Group one had a significant result compared with the collagen and control groups. In group one, significant wound healing and wound contraction were observed with 52% and 80% wound contraction at 7 and 14 days, respectively. CONCLUSION: Collagen/ADSCs can be considered a suitable candidate hydrogel in wound healing with a high potential for enhancing wound repairing.
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spelling pubmed-98569982023-01-24 The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study Abbasi, Kamyar Tavakolizadeh, Sara Hadi, Alireza Hosseini, Maryam Soufdoost, Reza Sayyad Heboyan, Artak Alam, Mostafa Fani‐Hanifeh, Sadaf Vet Med Sci RODENTS BACKGROUND: The complex wound healing process involves activating and synchronizing intracellular, intercellular, and extracellular components. Adipose tissue is attracting attention to promote wound healing. Within subcutaneous adipose tissue, stromal vascular cells and their subsets release growth factors and cytokines critical for neovascularization and wound repair. OBJECTIVES: This study evaluated human placental collagen/adipose‐derived stem cells (ADSCs) hydrogel for wound healing in rats. METHODS: In this study, ADSCs were harvested, cultured, and mixed with placental collagen. Twelve rats were used, and their backs were excised three times each. Group one received collagen/ADSCs, group two collagen, and group three non‐filled (control) excisions. The healing processes were assessed by histological analysis, taking photographs, and calculating the percentage of wound contraction in mentioned times. RESULTS: Histopathological analysis revealed that the content of fibroblasts, follicles of the hair, and angiogenesis in group one was significantly more than in other groups. Group one had a significant result compared with the collagen and control groups. In group one, significant wound healing and wound contraction were observed with 52% and 80% wound contraction at 7 and 14 days, respectively. CONCLUSION: Collagen/ADSCs can be considered a suitable candidate hydrogel in wound healing with a high potential for enhancing wound repairing. John Wiley and Sons Inc. 2022-12-26 /pmc/articles/PMC9856998/ /pubmed/36571812 http://dx.doi.org/10.1002/vms3.1059 Text en © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle RODENTS
Abbasi, Kamyar
Tavakolizadeh, Sara
Hadi, Alireza
Hosseini, Maryam
Soufdoost, Reza Sayyad
Heboyan, Artak
Alam, Mostafa
Fani‐Hanifeh, Sadaf
The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title_full The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title_fullStr The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title_full_unstemmed The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title_short The wound healing effect of collagen/adipose‐derived stem cells (ADSCs) hydrogel: In vivo study
title_sort wound healing effect of collagen/adipose‐derived stem cells (adscs) hydrogel: in vivo study
topic RODENTS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856998/
https://www.ncbi.nlm.nih.gov/pubmed/36571812
http://dx.doi.org/10.1002/vms3.1059
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