Cargando…
Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857165/ https://www.ncbi.nlm.nih.gov/pubmed/36670711 http://dx.doi.org/10.3390/children10010161 |
_version_ | 1784873805575880704 |
---|---|
author | Kim, Maro Lee, Jin Hee Kwak, Young Ho Kim, Hyun Kyung Kwon, Hyuksool Suh, Dongbum Kim, Do Kyun Lee, Ha Ni Kim, Jin Hee Jue, Jie Hee Hwang, Soyun |
author_facet | Kim, Maro Lee, Jin Hee Kwak, Young Ho Kim, Hyun Kyung Kwon, Hyuksool Suh, Dongbum Kim, Do Kyun Lee, Ha Ni Kim, Jin Hee Jue, Jie Hee Hwang, Soyun |
author_sort | Kim, Maro |
collection | PubMed |
description | Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI) in pediatric febrile patients in the emergency department (ED). Method: We conducted a retrospective analysis of febrile patients’ medical records from the pediatric ED of the teaching hospital. The patients with BIWB and those with VI were identified with a review of medical records. The primary outcome was the diagnostic performance of DNI in differentiating BIWB from VI. The secondary outcome was a comparison of the diagnostic performances of DNI, CRP, WBC, and neutrophil count between the two groups. Results: A total of 151 (26.3%) patients were in the BIWB group, and 423 (73.7%) were in the VI group. There was no significant difference in DNI between the two groups (3.51 ± 6.90 vs. 3.07 ± 5.82, mean ± SD, BIWB vs. VI). However, CRP levels were significantly higher in the BIWB group than in the VI group (4.56 ± 5.45 vs. 1.39 ± 2.12, mean ± SD, BIWB vs. VI, p < 0.05). The AUROCs of DNI, WBC count, neutrophil levels, RDW, and CRP levels were 0.5016, 0.5531, 0.5631, 0.5131, and 0.7389, respectively, and only CRP levels were helpful in differentiating BIWB from VI. Conclusion: In the absence of bacteremia, DNI would not be helpful in differentiating BIWB from VI in pediatric febrile patients. |
format | Online Article Text |
id | pubmed-9857165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98571652023-01-21 Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients Kim, Maro Lee, Jin Hee Kwak, Young Ho Kim, Hyun Kyung Kwon, Hyuksool Suh, Dongbum Kim, Do Kyun Lee, Ha Ni Kim, Jin Hee Jue, Jie Hee Hwang, Soyun Children (Basel) Article Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI) in pediatric febrile patients in the emergency department (ED). Method: We conducted a retrospective analysis of febrile patients’ medical records from the pediatric ED of the teaching hospital. The patients with BIWB and those with VI were identified with a review of medical records. The primary outcome was the diagnostic performance of DNI in differentiating BIWB from VI. The secondary outcome was a comparison of the diagnostic performances of DNI, CRP, WBC, and neutrophil count between the two groups. Results: A total of 151 (26.3%) patients were in the BIWB group, and 423 (73.7%) were in the VI group. There was no significant difference in DNI between the two groups (3.51 ± 6.90 vs. 3.07 ± 5.82, mean ± SD, BIWB vs. VI). However, CRP levels were significantly higher in the BIWB group than in the VI group (4.56 ± 5.45 vs. 1.39 ± 2.12, mean ± SD, BIWB vs. VI, p < 0.05). The AUROCs of DNI, WBC count, neutrophil levels, RDW, and CRP levels were 0.5016, 0.5531, 0.5631, 0.5131, and 0.7389, respectively, and only CRP levels were helpful in differentiating BIWB from VI. Conclusion: In the absence of bacteremia, DNI would not be helpful in differentiating BIWB from VI in pediatric febrile patients. MDPI 2023-01-14 /pmc/articles/PMC9857165/ /pubmed/36670711 http://dx.doi.org/10.3390/children10010161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Maro Lee, Jin Hee Kwak, Young Ho Kim, Hyun Kyung Kwon, Hyuksool Suh, Dongbum Kim, Do Kyun Lee, Ha Ni Kim, Jin Hee Jue, Jie Hee Hwang, Soyun Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title | Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title_full | Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title_fullStr | Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title_full_unstemmed | Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title_short | Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients |
title_sort | delta neutrophil index does not differentiate bacterial infection without bacteremia from viral infection in pediatric febrile patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857165/ https://www.ncbi.nlm.nih.gov/pubmed/36670711 http://dx.doi.org/10.3390/children10010161 |
work_keys_str_mv | AT kimmaro deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT leejinhee deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT kwakyoungho deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT kimhyunkyung deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT kwonhyuksool deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT suhdongbum deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT kimdokyun deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT leehani deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT kimjinhee deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT juejiehee deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients AT hwangsoyun deltaneutrophilindexdoesnotdifferentiatebacterialinfectionwithoutbacteremiafromviralinfectioninpediatricfebrilepatients |