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Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients

Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI...

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Autores principales: Kim, Maro, Lee, Jin Hee, Kwak, Young Ho, Kim, Hyun Kyung, Kwon, Hyuksool, Suh, Dongbum, Kim, Do Kyun, Lee, Ha Ni, Kim, Jin Hee, Jue, Jie Hee, Hwang, Soyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857165/
https://www.ncbi.nlm.nih.gov/pubmed/36670711
http://dx.doi.org/10.3390/children10010161
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author Kim, Maro
Lee, Jin Hee
Kwak, Young Ho
Kim, Hyun Kyung
Kwon, Hyuksool
Suh, Dongbum
Kim, Do Kyun
Lee, Ha Ni
Kim, Jin Hee
Jue, Jie Hee
Hwang, Soyun
author_facet Kim, Maro
Lee, Jin Hee
Kwak, Young Ho
Kim, Hyun Kyung
Kwon, Hyuksool
Suh, Dongbum
Kim, Do Kyun
Lee, Ha Ni
Kim, Jin Hee
Jue, Jie Hee
Hwang, Soyun
author_sort Kim, Maro
collection PubMed
description Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI) in pediatric febrile patients in the emergency department (ED). Method: We conducted a retrospective analysis of febrile patients’ medical records from the pediatric ED of the teaching hospital. The patients with BIWB and those with VI were identified with a review of medical records. The primary outcome was the diagnostic performance of DNI in differentiating BIWB from VI. The secondary outcome was a comparison of the diagnostic performances of DNI, CRP, WBC, and neutrophil count between the two groups. Results: A total of 151 (26.3%) patients were in the BIWB group, and 423 (73.7%) were in the VI group. There was no significant difference in DNI between the two groups (3.51 ± 6.90 vs. 3.07 ± 5.82, mean ± SD, BIWB vs. VI). However, CRP levels were significantly higher in the BIWB group than in the VI group (4.56 ± 5.45 vs. 1.39 ± 2.12, mean ± SD, BIWB vs. VI, p < 0.05). The AUROCs of DNI, WBC count, neutrophil levels, RDW, and CRP levels were 0.5016, 0.5531, 0.5631, 0.5131, and 0.7389, respectively, and only CRP levels were helpful in differentiating BIWB from VI. Conclusion: In the absence of bacteremia, DNI would not be helpful in differentiating BIWB from VI in pediatric febrile patients.
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spelling pubmed-98571652023-01-21 Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients Kim, Maro Lee, Jin Hee Kwak, Young Ho Kim, Hyun Kyung Kwon, Hyuksool Suh, Dongbum Kim, Do Kyun Lee, Ha Ni Kim, Jin Hee Jue, Jie Hee Hwang, Soyun Children (Basel) Article Introduction: We sought to determine whether the delta neutrophil index (DNI), a marker that is reported to be used to predict the diagnosis, prognosis, and disease severity of bacteremia and sepsis, is useful in differentiating bacterial infection without bacteremia (BIWB) from viral infections (VI) in pediatric febrile patients in the emergency department (ED). Method: We conducted a retrospective analysis of febrile patients’ medical records from the pediatric ED of the teaching hospital. The patients with BIWB and those with VI were identified with a review of medical records. The primary outcome was the diagnostic performance of DNI in differentiating BIWB from VI. The secondary outcome was a comparison of the diagnostic performances of DNI, CRP, WBC, and neutrophil count between the two groups. Results: A total of 151 (26.3%) patients were in the BIWB group, and 423 (73.7%) were in the VI group. There was no significant difference in DNI between the two groups (3.51 ± 6.90 vs. 3.07 ± 5.82, mean ± SD, BIWB vs. VI). However, CRP levels were significantly higher in the BIWB group than in the VI group (4.56 ± 5.45 vs. 1.39 ± 2.12, mean ± SD, BIWB vs. VI, p < 0.05). The AUROCs of DNI, WBC count, neutrophil levels, RDW, and CRP levels were 0.5016, 0.5531, 0.5631, 0.5131, and 0.7389, respectively, and only CRP levels were helpful in differentiating BIWB from VI. Conclusion: In the absence of bacteremia, DNI would not be helpful in differentiating BIWB from VI in pediatric febrile patients. MDPI 2023-01-14 /pmc/articles/PMC9857165/ /pubmed/36670711 http://dx.doi.org/10.3390/children10010161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Maro
Lee, Jin Hee
Kwak, Young Ho
Kim, Hyun Kyung
Kwon, Hyuksool
Suh, Dongbum
Kim, Do Kyun
Lee, Ha Ni
Kim, Jin Hee
Jue, Jie Hee
Hwang, Soyun
Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title_full Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title_fullStr Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title_full_unstemmed Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title_short Delta Neutrophil Index Does Not Differentiate Bacterial Infection without Bacteremia from Viral Infection in Pediatric Febrile Patients
title_sort delta neutrophil index does not differentiate bacterial infection without bacteremia from viral infection in pediatric febrile patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857165/
https://www.ncbi.nlm.nih.gov/pubmed/36670711
http://dx.doi.org/10.3390/children10010161
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