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Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer

The integration of precision medicine in the care of hospitalized children is ever evolving. However, access to new genomic diagnostics such as rapid whole genome sequencing (rWGS) is hindered by barriers in implementation. Michigan’s Project Baby Deer (PBD) is a multi-center collaborative effort th...

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Autores principales: Bupp, Caleb P., Ames, Elizabeth G., Arenchild, Madison K., Caylor, Sara, Dimmock, David P., Fakhoury, Joseph D., Karna, Padmani, Lehman, April, Meghea, Cristian I., Misra, Vinod, Nolan, Danielle A., O’Shea, Jessica, Sharangpani, Aditi, Franck, Linda S., Scheurer-Monaghan, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857227/
https://www.ncbi.nlm.nih.gov/pubmed/36670656
http://dx.doi.org/10.3390/children10010106
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author Bupp, Caleb P.
Ames, Elizabeth G.
Arenchild, Madison K.
Caylor, Sara
Dimmock, David P.
Fakhoury, Joseph D.
Karna, Padmani
Lehman, April
Meghea, Cristian I.
Misra, Vinod
Nolan, Danielle A.
O’Shea, Jessica
Sharangpani, Aditi
Franck, Linda S.
Scheurer-Monaghan, Andrea
author_facet Bupp, Caleb P.
Ames, Elizabeth G.
Arenchild, Madison K.
Caylor, Sara
Dimmock, David P.
Fakhoury, Joseph D.
Karna, Padmani
Lehman, April
Meghea, Cristian I.
Misra, Vinod
Nolan, Danielle A.
O’Shea, Jessica
Sharangpani, Aditi
Franck, Linda S.
Scheurer-Monaghan, Andrea
author_sort Bupp, Caleb P.
collection PubMed
description The integration of precision medicine in the care of hospitalized children is ever evolving. However, access to new genomic diagnostics such as rapid whole genome sequencing (rWGS) is hindered by barriers in implementation. Michigan’s Project Baby Deer (PBD) is a multi-center collaborative effort that sought to break down barriers to access by offering rWGS to critically ill neonatal and pediatric inpatients in Michigan. The clinical champion team used a standardized approach with inclusion and exclusion criteria, shared learning, and quality improvement evaluation of the project’s impact on the clinical outcomes and economics of inpatient rWGS. Hospitals, including those without on-site geneticists or genetic counselors, noted positive clinical impacts, accelerating time to definitive treatment for project patients. Between 95–214 hospital days were avoided, net savings of $4155 per patient, and family experience of care was improved. The project spurred policy advancement when Michigan became the first state in the United States to have a Medicaid policy with carve-out payment to hospitals for rWGS testing. This state project demonstrates how front-line clinician champions can directly improve access to new technology for pediatric patients and serves as a roadmap for expanding clinical implementation of evidence-based precision medicine technologies.
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spelling pubmed-98572272023-01-21 Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer Bupp, Caleb P. Ames, Elizabeth G. Arenchild, Madison K. Caylor, Sara Dimmock, David P. Fakhoury, Joseph D. Karna, Padmani Lehman, April Meghea, Cristian I. Misra, Vinod Nolan, Danielle A. O’Shea, Jessica Sharangpani, Aditi Franck, Linda S. Scheurer-Monaghan, Andrea Children (Basel) Article The integration of precision medicine in the care of hospitalized children is ever evolving. However, access to new genomic diagnostics such as rapid whole genome sequencing (rWGS) is hindered by barriers in implementation. Michigan’s Project Baby Deer (PBD) is a multi-center collaborative effort that sought to break down barriers to access by offering rWGS to critically ill neonatal and pediatric inpatients in Michigan. The clinical champion team used a standardized approach with inclusion and exclusion criteria, shared learning, and quality improvement evaluation of the project’s impact on the clinical outcomes and economics of inpatient rWGS. Hospitals, including those without on-site geneticists or genetic counselors, noted positive clinical impacts, accelerating time to definitive treatment for project patients. Between 95–214 hospital days were avoided, net savings of $4155 per patient, and family experience of care was improved. The project spurred policy advancement when Michigan became the first state in the United States to have a Medicaid policy with carve-out payment to hospitals for rWGS testing. This state project demonstrates how front-line clinician champions can directly improve access to new technology for pediatric patients and serves as a roadmap for expanding clinical implementation of evidence-based precision medicine technologies. MDPI 2023-01-04 /pmc/articles/PMC9857227/ /pubmed/36670656 http://dx.doi.org/10.3390/children10010106 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bupp, Caleb P.
Ames, Elizabeth G.
Arenchild, Madison K.
Caylor, Sara
Dimmock, David P.
Fakhoury, Joseph D.
Karna, Padmani
Lehman, April
Meghea, Cristian I.
Misra, Vinod
Nolan, Danielle A.
O’Shea, Jessica
Sharangpani, Aditi
Franck, Linda S.
Scheurer-Monaghan, Andrea
Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title_full Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title_fullStr Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title_full_unstemmed Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title_short Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan’s Project Baby Deer
title_sort breaking barriers to rapid whole genome sequencing in pediatrics: michigan’s project baby deer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857227/
https://www.ncbi.nlm.nih.gov/pubmed/36670656
http://dx.doi.org/10.3390/children10010106
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