Pyruvate Dehydrogenase Inhibition Leads to Decreased Glycolysis, Increased Reliance on Gluconeogenesis and Alternative Sources of Acetyl-CoA in Acute Myeloid Leukemia

SIMPLE SUMMARY: Acute myeloid leukemia (AML) is an aggressive cancer with poor outcomes that needs new treatments. One new approach to treat AML is to target its metabolism. A large phase III clinical trial using a metabolic inhibitor, devimistat, did not show any benefit for patients. One reason co...

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Detalles Bibliográficos
Autores principales: Anderson, Rebecca, Pladna, Kristin M., Schramm, Nathaniel J., Wheeler, Frances B., Kridel, Steven, Pardee, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857304/
https://www.ncbi.nlm.nih.gov/pubmed/36672433
http://dx.doi.org/10.3390/cancers15020484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857304/
https://www.ncbi.nlm.nih.gov/pubmed/36672433
http://dx.doi.org/10.3390/cancers15020484

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