Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer: A Correlative Analysis of the CALGB 40601 and PAMELA Trials

IMPORTANCE: Both tumor-infiltrating lymphocytes (TILs) assessment and immune-related gene expression signatures by RNA profiling predict higher pathologic complete response (pCR) and improved event-free survival (EFS) in patients with early-stage ERBB2/HER2-positive breast cancer. However, whether t...

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Detalles Bibliográficos
Autores principales: Fernandez-Martinez, Aranzazu, Pascual, Tomás, Singh, Baljit, Nuciforo, Paolo, Rashid, Naim U., Ballman, Karla V., Campbell, Jordan D., Hoadley, Katherine A., Spears, Patricia A., Pare, Laia, Brasó-Maristany, Fara, Chic, Nuria, Krop, Ian, Partridge, Ann, Cortés, Javier, Llombart-Cussac, Antonio, Prat, Aleix, Perou, Charles M., Carey, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857319/
https://www.ncbi.nlm.nih.gov/pubmed/36602784
http://dx.doi.org/10.1001/jamaoncol.2022.6288

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