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Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention
The aim of this study was to analyze variation in body mass index (BMI) and skeletal muscle index (SMI) in head and neck squamous cell carcinoma (HNSCC) patients who underwent exclusive radiotherapy (RT) or concurrent chemo-radiotherapy (RT-CHT). We enrolled 73 HNSCC pts treated with definitive or p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857332/ https://www.ncbi.nlm.nih.gov/pubmed/36661669 http://dx.doi.org/10.3390/curroncol30010020 |
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author | Pisani, Carla Mastroleo, Federico Collo, Alessandro Ferrante, Daniela Carabelli, Greta Franco, Pierfrancesco Riso, Sergio Dell’Era, Valeria Garzaro, Massimiliano Aluffi Valletti, Paolo Krengli, Marco |
author_facet | Pisani, Carla Mastroleo, Federico Collo, Alessandro Ferrante, Daniela Carabelli, Greta Franco, Pierfrancesco Riso, Sergio Dell’Era, Valeria Garzaro, Massimiliano Aluffi Valletti, Paolo Krengli, Marco |
author_sort | Pisani, Carla |
collection | PubMed |
description | The aim of this study was to analyze variation in body mass index (BMI) and skeletal muscle index (SMI) in head and neck squamous cell carcinoma (HNSCC) patients who underwent exclusive radiotherapy (RT) or concurrent chemo-radiotherapy (RT-CHT). We enrolled 73 HNSCC pts treated with definitive or post-operative RT (14 pts) or RT-CHT (59 pts). At the time of diagnosis (t(0)) and 3 months after treatment completion (t(3)), CT scans were retrieved to measure skeletal muscle at the level of the C3 vertebra. Median follow-up was 16 months. Nine disease progressions with distant metastases and eleven local relapses were observed. Fifty-three pts were free from progression at 1 year. At t(0), average BMI was 25.8 (SD 4.1), while at t(3) it was 24.5, with no reduction in 54 pts. A BMI decrease of −1.3 (p-value < 0.0001) between t(0) and t(3) was found with the Wilcoxon signed-rank test. SMI was 57.1 and 59.2 at t(0) and t(3), respectively (p-value = 0.005). According to our analysis, SMI variation seems to reflect the effect of an appropriate nutritional intervention and may represent a reliable, simple tool for muscle mass analysis. |
format | Online Article Text |
id | pubmed-9857332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98573322023-01-21 Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention Pisani, Carla Mastroleo, Federico Collo, Alessandro Ferrante, Daniela Carabelli, Greta Franco, Pierfrancesco Riso, Sergio Dell’Era, Valeria Garzaro, Massimiliano Aluffi Valletti, Paolo Krengli, Marco Curr Oncol Article The aim of this study was to analyze variation in body mass index (BMI) and skeletal muscle index (SMI) in head and neck squamous cell carcinoma (HNSCC) patients who underwent exclusive radiotherapy (RT) or concurrent chemo-radiotherapy (RT-CHT). We enrolled 73 HNSCC pts treated with definitive or post-operative RT (14 pts) or RT-CHT (59 pts). At the time of diagnosis (t(0)) and 3 months after treatment completion (t(3)), CT scans were retrieved to measure skeletal muscle at the level of the C3 vertebra. Median follow-up was 16 months. Nine disease progressions with distant metastases and eleven local relapses were observed. Fifty-three pts were free from progression at 1 year. At t(0), average BMI was 25.8 (SD 4.1), while at t(3) it was 24.5, with no reduction in 54 pts. A BMI decrease of −1.3 (p-value < 0.0001) between t(0) and t(3) was found with the Wilcoxon signed-rank test. SMI was 57.1 and 59.2 at t(0) and t(3), respectively (p-value = 0.005). According to our analysis, SMI variation seems to reflect the effect of an appropriate nutritional intervention and may represent a reliable, simple tool for muscle mass analysis. MDPI 2022-12-24 /pmc/articles/PMC9857332/ /pubmed/36661669 http://dx.doi.org/10.3390/curroncol30010020 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pisani, Carla Mastroleo, Federico Collo, Alessandro Ferrante, Daniela Carabelli, Greta Franco, Pierfrancesco Riso, Sergio Dell’Era, Valeria Garzaro, Massimiliano Aluffi Valletti, Paolo Krengli, Marco Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title | Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title_full | Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title_fullStr | Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title_full_unstemmed | Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title_short | Variation in Body Mass and Skeletal Muscle Indices in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy and Nutritional Intervention |
title_sort | variation in body mass and skeletal muscle indices in head and neck cancer patients undergoing (chemo)radiotherapy and nutritional intervention |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857332/ https://www.ncbi.nlm.nih.gov/pubmed/36661669 http://dx.doi.org/10.3390/curroncol30010020 |
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