PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice. In this study, we purified the prenylated cargo of PDE...

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Detalles Bibliográficos
Autores principales: Faber, Siebren, Letteboer, Stef J. F., Junger, Katrin, Butcher, Rossano, Tammana, Trinadh V. Satish, van Beersum, Sylvia E. C., Ueffing, Marius, Collin, Rob W. J., Liu, Qin, Boldt, Karsten, Roepman, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857354/
https://www.ncbi.nlm.nih.gov/pubmed/36672247
http://dx.doi.org/10.3390/cells12020312

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