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Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study

In this study, we analyzed blood zinc concentration in patients with various cancer types and the degree of improvement in relation to the underlying disease following treatment with zinc preparations. Serum zinc levels of 530 cancer patients whose blood zinc levels were measured at our hospital fro...

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Autores principales: Sugimoto, Rie, Tanaka, Yuki, Senju, Takeshi, Morita, Yusuke, Lee, Lingaku, Hijioka, Masayuki, Hisano, Terumasa, Furukawa, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857535/
https://www.ncbi.nlm.nih.gov/pubmed/36701704
http://dx.doi.org/10.1097/MD.0000000000032703
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author Sugimoto, Rie
Tanaka, Yuki
Senju, Takeshi
Morita, Yusuke
Lee, Lingaku
Hijioka, Masayuki
Hisano, Terumasa
Furukawa, Masayuki
author_facet Sugimoto, Rie
Tanaka, Yuki
Senju, Takeshi
Morita, Yusuke
Lee, Lingaku
Hijioka, Masayuki
Hisano, Terumasa
Furukawa, Masayuki
author_sort Sugimoto, Rie
collection PubMed
description In this study, we analyzed blood zinc concentration in patients with various cancer types and the degree of improvement in relation to the underlying disease following treatment with zinc preparations. Serum zinc levels of 530 cancer patients whose blood zinc levels were measured at our hospital from 2016 to 2021 were retrospectively examined in accordance with the primary disease. Changes in zinc levels were analyzed in 155 patients whose zinc levels had been measured on 2 or more occasions in accordance with whether they had received zinc preparations. In addition, the concentration course of zinc before and after zinc formulation administration in 73 patients was examined in accordance with the presence or absence of liver cirrhosis complications. Mean serum zinc levels were below normal in all carcinomas measured, and zinc levels were significantly lower in cirrhosis–hepatocarcinoma cases than in other primary disease cases. Furthermore, serum zinc levels in patients who did not receive zinc preparations decreased significantly over time. In patients who received zinc preparations, the elevated levels of zinc after treatment were significantly lower in patients with cirrhosis than in those without cirrhosis. There was a weak inverse correlation between pre-dose zinc concentration and increased zinc concentration in patients with cirrhosis. In the analysis of covariance, the presence of liver cirrhosis was predominantly correlated with elevated zinc per dose. In summary, serum zinc levels in cancer patients are low and especially low in cancer patients with liver cirrhosis compared with those without cirrhosis after the administration of zinc preparations.
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spelling pubmed-98575352023-01-24 Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study Sugimoto, Rie Tanaka, Yuki Senju, Takeshi Morita, Yusuke Lee, Lingaku Hijioka, Masayuki Hisano, Terumasa Furukawa, Masayuki Medicine (Baltimore) 5500 In this study, we analyzed blood zinc concentration in patients with various cancer types and the degree of improvement in relation to the underlying disease following treatment with zinc preparations. Serum zinc levels of 530 cancer patients whose blood zinc levels were measured at our hospital from 2016 to 2021 were retrospectively examined in accordance with the primary disease. Changes in zinc levels were analyzed in 155 patients whose zinc levels had been measured on 2 or more occasions in accordance with whether they had received zinc preparations. In addition, the concentration course of zinc before and after zinc formulation administration in 73 patients was examined in accordance with the presence or absence of liver cirrhosis complications. Mean serum zinc levels were below normal in all carcinomas measured, and zinc levels were significantly lower in cirrhosis–hepatocarcinoma cases than in other primary disease cases. Furthermore, serum zinc levels in patients who did not receive zinc preparations decreased significantly over time. In patients who received zinc preparations, the elevated levels of zinc after treatment were significantly lower in patients with cirrhosis than in those without cirrhosis. There was a weak inverse correlation between pre-dose zinc concentration and increased zinc concentration in patients with cirrhosis. In the analysis of covariance, the presence of liver cirrhosis was predominantly correlated with elevated zinc per dose. In summary, serum zinc levels in cancer patients are low and especially low in cancer patients with liver cirrhosis compared with those without cirrhosis after the administration of zinc preparations. Lippincott Williams & Wilkins 2023-01-20 /pmc/articles/PMC9857535/ /pubmed/36701704 http://dx.doi.org/10.1097/MD.0000000000032703 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5500
Sugimoto, Rie
Tanaka, Yuki
Senju, Takeshi
Morita, Yusuke
Lee, Lingaku
Hijioka, Masayuki
Hisano, Terumasa
Furukawa, Masayuki
Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title_full Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title_fullStr Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title_full_unstemmed Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title_short Serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: A retrospective study
title_sort serum zinc levels in cancer patients are low and difficult to elevate when complicated by liver cirrhosis: a retrospective study
topic 5500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857535/
https://www.ncbi.nlm.nih.gov/pubmed/36701704
http://dx.doi.org/10.1097/MD.0000000000032703
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