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Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature

Background: Giant gallbladder is an uncommon condition that can result from a benign pathology and rarely presents with malignancy. Intracholecystic papillary–tubular neoplasm (ICPN) is a relatively new entity first described by V. Adsay in 2012 and included in the World Health Classification of Dig...

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Autores principales: Constantin, Adrian, Achim, Florin, Turcu, Tudor, Birceanu, Adelina, Evsei, Anca, Socea, Bogdan, Predescu, Dragos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857600/
https://www.ncbi.nlm.nih.gov/pubmed/36673003
http://dx.doi.org/10.3390/diagnostics13020194
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author Constantin, Adrian
Achim, Florin
Turcu, Tudor
Birceanu, Adelina
Evsei, Anca
Socea, Bogdan
Predescu, Dragos
author_facet Constantin, Adrian
Achim, Florin
Turcu, Tudor
Birceanu, Adelina
Evsei, Anca
Socea, Bogdan
Predescu, Dragos
author_sort Constantin, Adrian
collection PubMed
description Background: Giant gallbladder is an uncommon condition that can result from a benign pathology and rarely presents with malignancy. Intracholecystic papillary–tubular neoplasm (ICPN) is a relatively new entity first described by V. Adsay in 2012 and included in the World Health Classification of Digestive System Tumours in 2019. Intracholecystic papillary-tubular neoplasm is a preinvasive lesion with an incidence of around 1% that may present as four histologic subtypes—biliary, gastric, intestinal, or oncocytic—of which the biliary subtype has the highest risk of associated invasive cancer. Although invasive carcinoma is present in about 50% of cases of ICPN, these patients have a significantly better prognosis than those with usual gallbladder cancer, suggesting that the entities may have distinct biological signatures. Case report: A 77-year-old female presented to the hospital with progressive swelling in the right hemiabdomen, a loss of appetite, and weight loss. MRI highlighted a giant abdominal tumor located in the right hypochondrium and right abdominal flank with liver invasion (segment V). Preoperatively, a gallbladder 25 × 17 cm in size was noted, and the patient underwent radical cholecystectomy. It was surprising to find such a giant malignant gallbladder tumor, diagnosed as invasive poorly cohesive carcinoma associated with ICPN. Discussion: A megacholecyst is a rare discovery. Although most often found in benign pathologies, giant gallbladder cancer can be considered. The neoplastic features and the loco-regional extension of the tumor must be evaluated by imaging scans. Few cases of giant benign gallbladder have been reported in the literature; however, this appeared to be the largest resectable gallbladder carcinoma reported to date according to the literature. Conclusion: The stage of gallbladder neoplasia is not correlated with the size of the gallbladder. Regardless of tumor size, the prognosis seems to be directly related to the stage, morphology, and resectability.
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spelling pubmed-98576002023-01-21 Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature Constantin, Adrian Achim, Florin Turcu, Tudor Birceanu, Adelina Evsei, Anca Socea, Bogdan Predescu, Dragos Diagnostics (Basel) Case Report Background: Giant gallbladder is an uncommon condition that can result from a benign pathology and rarely presents with malignancy. Intracholecystic papillary–tubular neoplasm (ICPN) is a relatively new entity first described by V. Adsay in 2012 and included in the World Health Classification of Digestive System Tumours in 2019. Intracholecystic papillary-tubular neoplasm is a preinvasive lesion with an incidence of around 1% that may present as four histologic subtypes—biliary, gastric, intestinal, or oncocytic—of which the biliary subtype has the highest risk of associated invasive cancer. Although invasive carcinoma is present in about 50% of cases of ICPN, these patients have a significantly better prognosis than those with usual gallbladder cancer, suggesting that the entities may have distinct biological signatures. Case report: A 77-year-old female presented to the hospital with progressive swelling in the right hemiabdomen, a loss of appetite, and weight loss. MRI highlighted a giant abdominal tumor located in the right hypochondrium and right abdominal flank with liver invasion (segment V). Preoperatively, a gallbladder 25 × 17 cm in size was noted, and the patient underwent radical cholecystectomy. It was surprising to find such a giant malignant gallbladder tumor, diagnosed as invasive poorly cohesive carcinoma associated with ICPN. Discussion: A megacholecyst is a rare discovery. Although most often found in benign pathologies, giant gallbladder cancer can be considered. The neoplastic features and the loco-regional extension of the tumor must be evaluated by imaging scans. Few cases of giant benign gallbladder have been reported in the literature; however, this appeared to be the largest resectable gallbladder carcinoma reported to date according to the literature. Conclusion: The stage of gallbladder neoplasia is not correlated with the size of the gallbladder. Regardless of tumor size, the prognosis seems to be directly related to the stage, morphology, and resectability. MDPI 2023-01-05 /pmc/articles/PMC9857600/ /pubmed/36673003 http://dx.doi.org/10.3390/diagnostics13020194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Constantin, Adrian
Achim, Florin
Turcu, Tudor
Birceanu, Adelina
Evsei, Anca
Socea, Bogdan
Predescu, Dragos
Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title_full Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title_fullStr Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title_full_unstemmed Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title_short Giant Gallbladder Tumor, Unusual Cancer—Case Report and Short Review of Literature
title_sort giant gallbladder tumor, unusual cancer—case report and short review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857600/
https://www.ncbi.nlm.nih.gov/pubmed/36673003
http://dx.doi.org/10.3390/diagnostics13020194
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