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Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil

Introduction: Urinary CD80 has been shown to have good specificity for minimal change disease (MCD) in children. However, the investigation of circulating factors such as soluble urokinase plasminogen activator receptor (suPAR) as biomarkers of focal segmental glomerulosclerosis (FSGS) is quite cont...

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Autores principales: Zen, Renata de Cássia, Dominguez, Wagner Vasques, Braga, Ivone, dos Reis, Luciene Machado, Jorge, Lectícia Barbosa, Yu, Luis, Woronik, Viktoria, Dias, Cristiane Bitencourt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857681/
https://www.ncbi.nlm.nih.gov/pubmed/36673014
http://dx.doi.org/10.3390/diagnostics13020203
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author Zen, Renata de Cássia
Dominguez, Wagner Vasques
Braga, Ivone
dos Reis, Luciene Machado
Jorge, Lectícia Barbosa
Yu, Luis
Woronik, Viktoria
Dias, Cristiane Bitencourt
author_facet Zen, Renata de Cássia
Dominguez, Wagner Vasques
Braga, Ivone
dos Reis, Luciene Machado
Jorge, Lectícia Barbosa
Yu, Luis
Woronik, Viktoria
Dias, Cristiane Bitencourt
author_sort Zen, Renata de Cássia
collection PubMed
description Introduction: Urinary CD80 has been shown to have good specificity for minimal change disease (MCD) in children. However, the investigation of circulating factors such as soluble urokinase plasminogen activator receptor (suPAR) as biomarkers of focal segmental glomerulosclerosis (FSGS) is quite controversial. The objective of this study was to determine whether urinary CD80 and serum suPAR can be used for the diagnosis of MCD and FSGS, respectively, in the adult population of Brazil. We also attempted to determine whether those biomarkers assess the response to immunosuppressive treatment. Methods: This was a prospective study in which urine and blood samples were collected for analysis of CD80 and suPAR, respectively, only in the moment of renal biopsy, from patients undergoing to diagnostic renal biopsy. At and six months after biopsy, we analyzed serum creatinine, serum albumin, and proteinuria in order to evaluate the use of the CD80 and suPAR collected in diagnosis as markers of response to immunosuppressive treatment. In healthy controls were collected urinary CD80 and proteinuria, serum suPAR, and creatinine. Results: The results of 70 renal biopsies were grouped, by diagnosis, as follows: FSGS (n = 18); membranous nephropathy (n = 14); MCD (n = 5); and other glomerulopathies (n = 33). There was no significant difference among the groups in terms of the urinary CD80 levels, and serum suPAR was not significantly higher in the FSGS group, as would have been expected. Urinary CD80 correlated positively with nephrotic syndrome, regardless of the type of glomerular disease. Neither biomarker correlated with proteinuria at six months after biopsy. Conclusion: In adults, urinary CD80 can serve as a marker of nephrotic syndrome but is not specific for MCD, whereas serum suPAR does not appear to be useful as a diagnostic or treatment response marker.
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spelling pubmed-98576812023-01-21 Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil Zen, Renata de Cássia Dominguez, Wagner Vasques Braga, Ivone dos Reis, Luciene Machado Jorge, Lectícia Barbosa Yu, Luis Woronik, Viktoria Dias, Cristiane Bitencourt Diagnostics (Basel) Article Introduction: Urinary CD80 has been shown to have good specificity for minimal change disease (MCD) in children. However, the investigation of circulating factors such as soluble urokinase plasminogen activator receptor (suPAR) as biomarkers of focal segmental glomerulosclerosis (FSGS) is quite controversial. The objective of this study was to determine whether urinary CD80 and serum suPAR can be used for the diagnosis of MCD and FSGS, respectively, in the adult population of Brazil. We also attempted to determine whether those biomarkers assess the response to immunosuppressive treatment. Methods: This was a prospective study in which urine and blood samples were collected for analysis of CD80 and suPAR, respectively, only in the moment of renal biopsy, from patients undergoing to diagnostic renal biopsy. At and six months after biopsy, we analyzed serum creatinine, serum albumin, and proteinuria in order to evaluate the use of the CD80 and suPAR collected in diagnosis as markers of response to immunosuppressive treatment. In healthy controls were collected urinary CD80 and proteinuria, serum suPAR, and creatinine. Results: The results of 70 renal biopsies were grouped, by diagnosis, as follows: FSGS (n = 18); membranous nephropathy (n = 14); MCD (n = 5); and other glomerulopathies (n = 33). There was no significant difference among the groups in terms of the urinary CD80 levels, and serum suPAR was not significantly higher in the FSGS group, as would have been expected. Urinary CD80 correlated positively with nephrotic syndrome, regardless of the type of glomerular disease. Neither biomarker correlated with proteinuria at six months after biopsy. Conclusion: In adults, urinary CD80 can serve as a marker of nephrotic syndrome but is not specific for MCD, whereas serum suPAR does not appear to be useful as a diagnostic or treatment response marker. MDPI 2023-01-05 /pmc/articles/PMC9857681/ /pubmed/36673014 http://dx.doi.org/10.3390/diagnostics13020203 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zen, Renata de Cássia
Dominguez, Wagner Vasques
Braga, Ivone
dos Reis, Luciene Machado
Jorge, Lectícia Barbosa
Yu, Luis
Woronik, Viktoria
Dias, Cristiane Bitencourt
Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title_full Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title_fullStr Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title_full_unstemmed Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title_short Urinary CD80 and Serum suPAR as Biomarkers of Glomerular Disease among Adults in Brazil
title_sort urinary cd80 and serum supar as biomarkers of glomerular disease among adults in brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857681/
https://www.ncbi.nlm.nih.gov/pubmed/36673014
http://dx.doi.org/10.3390/diagnostics13020203
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