DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Fluoropyrimidine chemotherapy is associated with interpatient variability in toxicity. A major contributor to unpredictable and severe toxicity relates to single nucleotide variation (SNV) in dihydropyrimidine dehydrogenase (DPYD), the rate-limiting fluoropyrimidine metabolizing enzyme. In addition...

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Detalles Bibliográficos
Autores principales: Wigle, Theodore J., Medwid, Samantha, Ross, Cameron, Schwarz, Ute I., Kim, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857685/
https://www.ncbi.nlm.nih.gov/pubmed/36661700
http://dx.doi.org/10.3390/curroncol30010051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857685/
https://www.ncbi.nlm.nih.gov/pubmed/36661700
http://dx.doi.org/10.3390/curroncol30010051

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