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A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument

Diabetic sensorimotor polyneuropathy (DSPN) is a serious long-term complication of diabetes, which may lead to foot ulceration and amputation. Among the screening tools for DSPN, the Michigan neuropathy screening instrument (MNSI) is frequently deployed, but it lacks a straightforward rating of seve...

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Autores principales: Haque, Fahmida, Reaz, Mamun B. I., Chowdhury, Muhammad E. H., Shapiai, Mohd Ibrahim bin, Malik, Rayaz A., Alhatou, Mohammed, Kobashi, Syoji, Ara, Iffat, Ali, Sawal H. M., Bakar, Ahmad A. A., Bhuiyan, Mohammad Arif Sobhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857736/
https://www.ncbi.nlm.nih.gov/pubmed/36673074
http://dx.doi.org/10.3390/diagnostics13020264
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author Haque, Fahmida
Reaz, Mamun B. I.
Chowdhury, Muhammad E. H.
Shapiai, Mohd Ibrahim bin
Malik, Rayaz A.
Alhatou, Mohammed
Kobashi, Syoji
Ara, Iffat
Ali, Sawal H. M.
Bakar, Ahmad A. A.
Bhuiyan, Mohammad Arif Sobhan
author_facet Haque, Fahmida
Reaz, Mamun B. I.
Chowdhury, Muhammad E. H.
Shapiai, Mohd Ibrahim bin
Malik, Rayaz A.
Alhatou, Mohammed
Kobashi, Syoji
Ara, Iffat
Ali, Sawal H. M.
Bakar, Ahmad A. A.
Bhuiyan, Mohammad Arif Sobhan
author_sort Haque, Fahmida
collection PubMed
description Diabetic sensorimotor polyneuropathy (DSPN) is a serious long-term complication of diabetes, which may lead to foot ulceration and amputation. Among the screening tools for DSPN, the Michigan neuropathy screening instrument (MNSI) is frequently deployed, but it lacks a straightforward rating of severity. A DSPN severity grading system has been built and simulated for the MNSI, utilizing longitudinal data captured over 19 years from the Epidemiology of Diabetes Interventions and Complications (EDIC) trial. Machine learning algorithms were used to establish the MNSI factors and patient outcomes to characterise the features with the best ability to detect DSPN severity. A nomogram based on multivariable logistic regression was designed, developed and validated. The extra tree model was applied to identify the top seven ranked MNSI features that identified DSPN, namely vibration perception (R), 10-gm filament, previous diabetic neuropathy, vibration perception (L), presence of callus, deformities and fissure. The nomogram’s area under the curve (AUC) was 0.9421 and 0.946 for the internal and external datasets, respectively. The probability of DSPN was predicted from the nomogram and a DSPN severity grading system for MNSI was created using the probability score. An independent dataset was used to validate the model’s performance. The patients were divided into four different severity levels, i.e., absent, mild, moderate, and severe, with cut-off values of 10.50, 12.70 and 15.00 for a DSPN probability of less than 50, 75 and 100%, respectively. We provide an easy-to-use, straightforward and reproducible approach to determine prognosis in patients with DSPN.
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spelling pubmed-98577362023-01-21 A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument Haque, Fahmida Reaz, Mamun B. I. Chowdhury, Muhammad E. H. Shapiai, Mohd Ibrahim bin Malik, Rayaz A. Alhatou, Mohammed Kobashi, Syoji Ara, Iffat Ali, Sawal H. M. Bakar, Ahmad A. A. Bhuiyan, Mohammad Arif Sobhan Diagnostics (Basel) Article Diabetic sensorimotor polyneuropathy (DSPN) is a serious long-term complication of diabetes, which may lead to foot ulceration and amputation. Among the screening tools for DSPN, the Michigan neuropathy screening instrument (MNSI) is frequently deployed, but it lacks a straightforward rating of severity. A DSPN severity grading system has been built and simulated for the MNSI, utilizing longitudinal data captured over 19 years from the Epidemiology of Diabetes Interventions and Complications (EDIC) trial. Machine learning algorithms were used to establish the MNSI factors and patient outcomes to characterise the features with the best ability to detect DSPN severity. A nomogram based on multivariable logistic regression was designed, developed and validated. The extra tree model was applied to identify the top seven ranked MNSI features that identified DSPN, namely vibration perception (R), 10-gm filament, previous diabetic neuropathy, vibration perception (L), presence of callus, deformities and fissure. The nomogram’s area under the curve (AUC) was 0.9421 and 0.946 for the internal and external datasets, respectively. The probability of DSPN was predicted from the nomogram and a DSPN severity grading system for MNSI was created using the probability score. An independent dataset was used to validate the model’s performance. The patients were divided into four different severity levels, i.e., absent, mild, moderate, and severe, with cut-off values of 10.50, 12.70 and 15.00 for a DSPN probability of less than 50, 75 and 100%, respectively. We provide an easy-to-use, straightforward and reproducible approach to determine prognosis in patients with DSPN. MDPI 2023-01-11 /pmc/articles/PMC9857736/ /pubmed/36673074 http://dx.doi.org/10.3390/diagnostics13020264 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haque, Fahmida
Reaz, Mamun B. I.
Chowdhury, Muhammad E. H.
Shapiai, Mohd Ibrahim bin
Malik, Rayaz A.
Alhatou, Mohammed
Kobashi, Syoji
Ara, Iffat
Ali, Sawal H. M.
Bakar, Ahmad A. A.
Bhuiyan, Mohammad Arif Sobhan
A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title_full A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title_fullStr A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title_full_unstemmed A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title_short A Machine Learning-Based Severity Prediction Tool for the Michigan Neuropathy Screening Instrument
title_sort machine learning-based severity prediction tool for the michigan neuropathy screening instrument
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857736/
https://www.ncbi.nlm.nih.gov/pubmed/36673074
http://dx.doi.org/10.3390/diagnostics13020264
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