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Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy

Fournier gangrene (FG) is a life-threatening disease affecting the soft tissues of the genital, perineal, and perianal regions. This retrospective study aimed to summarize the characteristics of FG and evaluate the effects of negative-pressure wound therapy (NPWT). We analyzed clinical data of 36 pa...

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Autores principales: He, Rui, Li, Xiangyan, Xie, Kun, Wen, Bing, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857754/
https://www.ncbi.nlm.nih.gov/pubmed/36684293
http://dx.doi.org/10.3389/fsurg.2022.1075968
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author He, Rui
Li, Xiangyan
Xie, Kun
Wen, Bing
Qi, Xin
author_facet He, Rui
Li, Xiangyan
Xie, Kun
Wen, Bing
Qi, Xin
author_sort He, Rui
collection PubMed
description Fournier gangrene (FG) is a life-threatening disease affecting the soft tissues of the genital, perineal, and perianal regions. This retrospective study aimed to summarize the characteristics of FG and evaluate the effects of negative-pressure wound therapy (NPWT). We analyzed clinical data of 36 patients with FG admitted to our department. Thirty-four cases had perianal and external genital infections, and the other two had secondary infection of the urinary fistula after trauma and retroperitoneal abscess, respectively. Monomicrobial, polymicrobial, culture-negative, and fungal infections were identified in 16, 17, 2, and 1 cases, respectively. Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Klebsiella pneumoniae, and Staphylococcus haemolyticus were the most common pathogens. The mortality rate was 8%. Twenty-seven and nine patients were treated with NPWT (group A) and conventional dressing (group B), respectively. The length of stay was 38.0 ± 16.1 and 51.0 ± 17.3 days, number of operations were 3 (3,6) and 13 (4,17), and wound healing times were 39.2 ± 18.1 and 66.5 ± 17.1 days in groups A and B, respectively. Taken together, clinicians should always consider the possibility of perianal or external genital infections progressing to FG in the daily work, especially for patients with diabetes mellitus. Enterobacteriaceae, Enterococcus, and Staphylococcus haemolyticus are the most common causative pathogens, and NPWT is an effective adjuvant therapy for wound management with fewer operations and a shorter wound healing time.
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spelling pubmed-98577542023-01-21 Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy He, Rui Li, Xiangyan Xie, Kun Wen, Bing Qi, Xin Front Surg Surgery Fournier gangrene (FG) is a life-threatening disease affecting the soft tissues of the genital, perineal, and perianal regions. This retrospective study aimed to summarize the characteristics of FG and evaluate the effects of negative-pressure wound therapy (NPWT). We analyzed clinical data of 36 patients with FG admitted to our department. Thirty-four cases had perianal and external genital infections, and the other two had secondary infection of the urinary fistula after trauma and retroperitoneal abscess, respectively. Monomicrobial, polymicrobial, culture-negative, and fungal infections were identified in 16, 17, 2, and 1 cases, respectively. Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Klebsiella pneumoniae, and Staphylococcus haemolyticus were the most common pathogens. The mortality rate was 8%. Twenty-seven and nine patients were treated with NPWT (group A) and conventional dressing (group B), respectively. The length of stay was 38.0 ± 16.1 and 51.0 ± 17.3 days, number of operations were 3 (3,6) and 13 (4,17), and wound healing times were 39.2 ± 18.1 and 66.5 ± 17.1 days in groups A and B, respectively. Taken together, clinicians should always consider the possibility of perianal or external genital infections progressing to FG in the daily work, especially for patients with diabetes mellitus. Enterobacteriaceae, Enterococcus, and Staphylococcus haemolyticus are the most common causative pathogens, and NPWT is an effective adjuvant therapy for wound management with fewer operations and a shorter wound healing time. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9857754/ /pubmed/36684293 http://dx.doi.org/10.3389/fsurg.2022.1075968 Text en © 2023 He, Li, Xie, Wen and Qi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
He, Rui
Li, Xiangyan
Xie, Kun
Wen, Bing
Qi, Xin
Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title_full Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title_fullStr Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title_full_unstemmed Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title_short Characteristics of Fournier gangrene and evaluation of the effects of negative-pressure wound therapy
title_sort characteristics of fournier gangrene and evaluation of the effects of negative-pressure wound therapy
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857754/
https://www.ncbi.nlm.nih.gov/pubmed/36684293
http://dx.doi.org/10.3389/fsurg.2022.1075968
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