Cargando…
Towards a better understanding of diabetes mellitus using organoid models
Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms and cell lines. Organoid models for a wide range of tissues are emerging as an additional tool enabling the study of diabetes mellitus. The applications for organoid models...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857923/ https://www.ncbi.nlm.nih.gov/pubmed/36670309 http://dx.doi.org/10.1038/s41574-022-00797-x |
_version_ | 1784873969764007936 |
---|---|
author | Beydag-Tasöz, Belin Selcen Yennek, Siham Grapin-Botton, Anne |
author_facet | Beydag-Tasöz, Belin Selcen Yennek, Siham Grapin-Botton, Anne |
author_sort | Beydag-Tasöz, Belin Selcen |
collection | PubMed |
description | Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms and cell lines. Organoid models for a wide range of tissues are emerging as an additional tool enabling the study of diabetes mellitus. The applications for organoid models include studying human pancreatic cell development, pancreatic physiology, the response of target organs to pancreatic hormones and how glucose toxicity can affect tissues such as the blood vessels, retina, kidney and nerves. Organoids can be derived from human tissue cells or pluripotent stem cells and enable the production of human cell assemblies mimicking human organs. Many organ mimics relevant to diabetes mellitus are already available, but only a few relevant studies have been performed. We discuss the models that have been developed for the pancreas, liver, kidney, nerves and vasculature, how they complement other models, and their limitations. In addition, as diabetes mellitus is a multi-organ disease, we highlight how a merger between the organoid and bioengineering fields will provide integrative models. |
format | Online Article Text |
id | pubmed-9857923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98579232023-01-23 Towards a better understanding of diabetes mellitus using organoid models Beydag-Tasöz, Belin Selcen Yennek, Siham Grapin-Botton, Anne Nat Rev Endocrinol Review Article Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms and cell lines. Organoid models for a wide range of tissues are emerging as an additional tool enabling the study of diabetes mellitus. The applications for organoid models include studying human pancreatic cell development, pancreatic physiology, the response of target organs to pancreatic hormones and how glucose toxicity can affect tissues such as the blood vessels, retina, kidney and nerves. Organoids can be derived from human tissue cells or pluripotent stem cells and enable the production of human cell assemblies mimicking human organs. Many organ mimics relevant to diabetes mellitus are already available, but only a few relevant studies have been performed. We discuss the models that have been developed for the pancreas, liver, kidney, nerves and vasculature, how they complement other models, and their limitations. In addition, as diabetes mellitus is a multi-organ disease, we highlight how a merger between the organoid and bioengineering fields will provide integrative models. Nature Publishing Group UK 2023-01-20 2023 /pmc/articles/PMC9857923/ /pubmed/36670309 http://dx.doi.org/10.1038/s41574-022-00797-x Text en © Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Beydag-Tasöz, Belin Selcen Yennek, Siham Grapin-Botton, Anne Towards a better understanding of diabetes mellitus using organoid models |
title | Towards a better understanding of diabetes mellitus using organoid models |
title_full | Towards a better understanding of diabetes mellitus using organoid models |
title_fullStr | Towards a better understanding of diabetes mellitus using organoid models |
title_full_unstemmed | Towards a better understanding of diabetes mellitus using organoid models |
title_short | Towards a better understanding of diabetes mellitus using organoid models |
title_sort | towards a better understanding of diabetes mellitus using organoid models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857923/ https://www.ncbi.nlm.nih.gov/pubmed/36670309 http://dx.doi.org/10.1038/s41574-022-00797-x |
work_keys_str_mv | AT beydagtasozbelinselcen towardsabetterunderstandingofdiabetesmellitususingorganoidmodels AT yenneksiham towardsabetterunderstandingofdiabetesmellitususingorganoidmodels AT grapinbottonanne towardsabetterunderstandingofdiabetesmellitususingorganoidmodels |