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CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall
Mantle cell lymphoma is a B-cell malignancy, which, in its classic form, usually involves lymph nodes and extranodal sites, and, among the extranodal sites, the gastrointestinal tract and the Waldeyer’s ring are most prevalent. MCL is rarely reported in the ocular adnexa, a site more frequently affe...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857961/ https://www.ncbi.nlm.nih.gov/pubmed/36661711 http://dx.doi.org/10.3390/curroncol30010062 |
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author | Zanelli, Magda Lugli, Alberto Palicelli, Andrea Sanguedolce, Francesca Zizzo, Maurizio Cresta, Camilla Biancafarina, Samuele Martino, Giovanni Crescenzi, Barbara Pancetti, Saverio Broggi, Giuseppe Caltabiano, Rosario Cimino, Luca Mecucci, Cristina Ascani, Stefano |
author_facet | Zanelli, Magda Lugli, Alberto Palicelli, Andrea Sanguedolce, Francesca Zizzo, Maurizio Cresta, Camilla Biancafarina, Samuele Martino, Giovanni Crescenzi, Barbara Pancetti, Saverio Broggi, Giuseppe Caltabiano, Rosario Cimino, Luca Mecucci, Cristina Ascani, Stefano |
author_sort | Zanelli, Magda |
collection | PubMed |
description | Mantle cell lymphoma is a B-cell malignancy, which, in its classic form, usually involves lymph nodes and extranodal sites, and, among the extranodal sites, the gastrointestinal tract and the Waldeyer’s ring are most prevalent. MCL is rarely reported in the ocular adnexa, a site more frequently affected by extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which is a form of low-grade malignancy. The diagnosis of MCL presenting in the ocular adnexa requires special attention as its rarity in this location combined with the not uncommon CD5 negativity of the disease when occurring in the ocular adnexa, may lead the pathologist to overlook the diagnosis and misinterpret MCL as marginal zone B cell lymphoma, which has a totally different behavior. Herein, we present a case of primary bilateral conjunctival CD5-negative MCL in a patient having no other sites affected by lymphoma and we discuss possible diagnostic pitfalls. |
format | Online Article Text |
id | pubmed-9857961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98579612023-01-21 CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall Zanelli, Magda Lugli, Alberto Palicelli, Andrea Sanguedolce, Francesca Zizzo, Maurizio Cresta, Camilla Biancafarina, Samuele Martino, Giovanni Crescenzi, Barbara Pancetti, Saverio Broggi, Giuseppe Caltabiano, Rosario Cimino, Luca Mecucci, Cristina Ascani, Stefano Curr Oncol Case Report Mantle cell lymphoma is a B-cell malignancy, which, in its classic form, usually involves lymph nodes and extranodal sites, and, among the extranodal sites, the gastrointestinal tract and the Waldeyer’s ring are most prevalent. MCL is rarely reported in the ocular adnexa, a site more frequently affected by extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which is a form of low-grade malignancy. The diagnosis of MCL presenting in the ocular adnexa requires special attention as its rarity in this location combined with the not uncommon CD5 negativity of the disease when occurring in the ocular adnexa, may lead the pathologist to overlook the diagnosis and misinterpret MCL as marginal zone B cell lymphoma, which has a totally different behavior. Herein, we present a case of primary bilateral conjunctival CD5-negative MCL in a patient having no other sites affected by lymphoma and we discuss possible diagnostic pitfalls. MDPI 2023-01-06 /pmc/articles/PMC9857961/ /pubmed/36661711 http://dx.doi.org/10.3390/curroncol30010062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Zanelli, Magda Lugli, Alberto Palicelli, Andrea Sanguedolce, Francesca Zizzo, Maurizio Cresta, Camilla Biancafarina, Samuele Martino, Giovanni Crescenzi, Barbara Pancetti, Saverio Broggi, Giuseppe Caltabiano, Rosario Cimino, Luca Mecucci, Cristina Ascani, Stefano CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title | CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title_full | CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title_fullStr | CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title_full_unstemmed | CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title_short | CD5-Negative Primary Mantle Cell Lymphoma Presenting with a Bilateral Conjunctival Mass: A Potential Diagnostic Pitfall |
title_sort | cd5-negative primary mantle cell lymphoma presenting with a bilateral conjunctival mass: a potential diagnostic pitfall |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857961/ https://www.ncbi.nlm.nih.gov/pubmed/36661711 http://dx.doi.org/10.3390/curroncol30010062 |
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