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An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule
A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FNAC) results. Three months later, the patient devel...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858021/ https://www.ncbi.nlm.nih.gov/pubmed/36673106 http://dx.doi.org/10.3390/diagnostics13020296 |
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author | Manta, Ringo Muteganya, Raoul Beun, Abraham J. Fallas, Jennifer Poppe, Kris G. |
author_facet | Manta, Ringo Muteganya, Raoul Beun, Abraham J. Fallas, Jennifer Poppe, Kris G. |
author_sort | Manta, Ringo |
collection | PubMed |
description | A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FNAC) results. Three months later, the patient developed mild shortness of breath, dry cough, and fever. Chest X-ray revealed a mild enlargement in the bilateral hilar regions. CT showed mediastinal and bilateral hilar enlarged lymph nodes and pulmonary micronodules. The workup was further completed with a (18)F-FDG PET/CT, showing intense FDG uptake in the mediastinal and bilateral hilar lymph nodes and increased uptake in the thyroid nodule. Endobronchial Ultrasound-guided Transbronchial needle aspiration (EBUS-TBNA) of a left hilar lymph node showed epithelioid non-necrotizing granulomas. Because of the FNAC results, size of the nodule and tracheal shift, thyroid lobectomy was performed one month later. Histopathological results also revealed multiple non-necrotizing epithelioid granulomas, suggesting systemic sarcoidosis with involvement of the thyroid. To our knowledge, this is the first report of thyroid sarcoidosis detected on (18)F-FDG PET/CT. Although an increased FDG uptake in a thyroid nodule is usually suggestive of thyroid malignancy, toxic nodule, or follicular hyperplasia, our case report shows that it could also suggest thyroid sarcoidosis. |
format | Online Article Text |
id | pubmed-9858021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98580212023-01-21 An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule Manta, Ringo Muteganya, Raoul Beun, Abraham J. Fallas, Jennifer Poppe, Kris G. Diagnostics (Basel) Interesting Images A 41-year-old female underwent a cervical spine CT for the workup of posterior neck pain irradiating to the shoulders for several months. An incidental thyroid nodule was found and classified as Bethesda III on the Fine-needle aspiration cytology (FNAC) results. Three months later, the patient developed mild shortness of breath, dry cough, and fever. Chest X-ray revealed a mild enlargement in the bilateral hilar regions. CT showed mediastinal and bilateral hilar enlarged lymph nodes and pulmonary micronodules. The workup was further completed with a (18)F-FDG PET/CT, showing intense FDG uptake in the mediastinal and bilateral hilar lymph nodes and increased uptake in the thyroid nodule. Endobronchial Ultrasound-guided Transbronchial needle aspiration (EBUS-TBNA) of a left hilar lymph node showed epithelioid non-necrotizing granulomas. Because of the FNAC results, size of the nodule and tracheal shift, thyroid lobectomy was performed one month later. Histopathological results also revealed multiple non-necrotizing epithelioid granulomas, suggesting systemic sarcoidosis with involvement of the thyroid. To our knowledge, this is the first report of thyroid sarcoidosis detected on (18)F-FDG PET/CT. Although an increased FDG uptake in a thyroid nodule is usually suggestive of thyroid malignancy, toxic nodule, or follicular hyperplasia, our case report shows that it could also suggest thyroid sarcoidosis. MDPI 2023-01-12 /pmc/articles/PMC9858021/ /pubmed/36673106 http://dx.doi.org/10.3390/diagnostics13020296 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Manta, Ringo Muteganya, Raoul Beun, Abraham J. Fallas, Jennifer Poppe, Kris G. An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title | An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title_full | An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title_fullStr | An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title_full_unstemmed | An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title_short | An Exceptional Cause of Increased (18)F-Fluorodeoxyglucose Uptake on PET/CT in a Thyroid Nodule |
title_sort | exceptional cause of increased (18)f-fluorodeoxyglucose uptake on pet/ct in a thyroid nodule |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858021/ https://www.ncbi.nlm.nih.gov/pubmed/36673106 http://dx.doi.org/10.3390/diagnostics13020296 |
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