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Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients

Background: Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 expression with various clinical and laboratory fin...

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Autores principales: Khalil, Mohamed, Elsharkawy, Nahla, Elmawardy, Mona Mohsen, Ayoub, Mahmoud Aly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858047/
https://www.ncbi.nlm.nih.gov/pubmed/36673136
http://dx.doi.org/10.3390/diagnostics13020325
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author Khalil, Mohamed
Elsharkawy, Nahla
Elmawardy, Mona Mohsen
Ayoub, Mahmoud Aly
author_facet Khalil, Mohamed
Elsharkawy, Nahla
Elmawardy, Mona Mohsen
Ayoub, Mahmoud Aly
author_sort Khalil, Mohamed
collection PubMed
description Background: Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 expression with various clinical and laboratory findings in 62 newly diagnosed acute lymphoblastic leukemia patients. Methods: All patients were subjected to full history taking, a thorough clinical examination, and laboratory investigations, which included complete blood count (CBC), BM aspiration, immunophenotyping of blast cells, and CD200 expression. Results: There is a higher statistically significant mean value of CD200 expression among the cases (66.15 ± 23.08) than the control group (0.37 ± 0.2) (p value ≤ 0.001). CD200 expression shows a significant correlation with total leucocytic count and hemoglobin level (p = 0.001, 0.03, respectively). Conclusions: This study showed that CD200 expression was expressed in 100% of the patients. Correlations between CD200 expression and different laboratory data of patients revealed that there was an impact of CD200 on different diagnostic findings. After the follow-up of the patients, we found that the use of PRISM function of the software could add value to the detection of minimal residual disease.
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spelling pubmed-98580472023-01-21 Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients Khalil, Mohamed Elsharkawy, Nahla Elmawardy, Mona Mohsen Ayoub, Mahmoud Aly Diagnostics (Basel) Article Background: Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 expression with various clinical and laboratory findings in 62 newly diagnosed acute lymphoblastic leukemia patients. Methods: All patients were subjected to full history taking, a thorough clinical examination, and laboratory investigations, which included complete blood count (CBC), BM aspiration, immunophenotyping of blast cells, and CD200 expression. Results: There is a higher statistically significant mean value of CD200 expression among the cases (66.15 ± 23.08) than the control group (0.37 ± 0.2) (p value ≤ 0.001). CD200 expression shows a significant correlation with total leucocytic count and hemoglobin level (p = 0.001, 0.03, respectively). Conclusions: This study showed that CD200 expression was expressed in 100% of the patients. Correlations between CD200 expression and different laboratory data of patients revealed that there was an impact of CD200 on different diagnostic findings. After the follow-up of the patients, we found that the use of PRISM function of the software could add value to the detection of minimal residual disease. MDPI 2023-01-16 /pmc/articles/PMC9858047/ /pubmed/36673136 http://dx.doi.org/10.3390/diagnostics13020325 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khalil, Mohamed
Elsharkawy, Nahla
Elmawardy, Mona Mohsen
Ayoub, Mahmoud Aly
Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title_full Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title_fullStr Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title_full_unstemmed Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title_short Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
title_sort prognostic role of cd200 in acute lymphoblastic leukemia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858047/
https://www.ncbi.nlm.nih.gov/pubmed/36673136
http://dx.doi.org/10.3390/diagnostics13020325
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