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Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography

Rigidity in Parkinson’s disease (PD) is assessed by clinical scales, mostly the Unified Parkinson’s Disease Rating Scale of the Movement Disorders Society (MDS-UPDRS). While the MDS-UPDRS-III ranges on an integer from 0 to 4, we investigated whether muscle ultrasound shear wave elastography (SWE) of...

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Autores principales: Oppold, Julia, Breu, Maria-Sophie, Gharabaghi, Alireza, Grimm, Alexander, Del Grosso, Nicholas A., Hormozi, Mohammad, Kleiser, Benedict, Klocke, Philipp, Kronlage, Cornelius, Weiß, Daniel, Marquetand, Justus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858214/
https://www.ncbi.nlm.nih.gov/pubmed/36673022
http://dx.doi.org/10.3390/diagnostics13020213
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author Oppold, Julia
Breu, Maria-Sophie
Gharabaghi, Alireza
Grimm, Alexander
Del Grosso, Nicholas A.
Hormozi, Mohammad
Kleiser, Benedict
Klocke, Philipp
Kronlage, Cornelius
Weiß, Daniel
Marquetand, Justus
author_facet Oppold, Julia
Breu, Maria-Sophie
Gharabaghi, Alireza
Grimm, Alexander
Del Grosso, Nicholas A.
Hormozi, Mohammad
Kleiser, Benedict
Klocke, Philipp
Kronlage, Cornelius
Weiß, Daniel
Marquetand, Justus
author_sort Oppold, Julia
collection PubMed
description Rigidity in Parkinson’s disease (PD) is assessed by clinical scales, mostly the Unified Parkinson’s Disease Rating Scale of the Movement Disorders Society (MDS-UPDRS). While the MDS-UPDRS-III ranges on an integer from 0 to 4, we investigated whether muscle ultrasound shear wave elastography (SWE) offers a refined assessment. Ten PD patients (five treated with deep brain stimulation (DBS) and levodopa, five with levodopa only) and ten healthy controls were included. Over a period of 80 min, both the SWE value and the item 22b-c of the MDS-UPDRS-III were measured at 5 min intervals. The measurements were performed bilaterally at the biceps brachii muscle (BB) and flexor digitorum profundus muscle in flexion and passive extension. Rigidity was modified and tracked under various therapeutic conditions (with and without medication/DBS). The feasibility of SWE for objective quantification was evaluated by correlation with the UPDRS-III: considering all positions and muscles, there was already a weak correlation (r = 0.01, p < 0.001)—in a targeted analysis, the BB in passive extension showed a markedly higher correlation (r = 0.494, p < 0.001). The application of dopaminergic medication and DBS resulted in statistically significant short-term changes in both clinical rigidity and SWE measurements in the BB (p < 0.001). We conclude that rigidity is reflected in the SWE measurements, indicating that SWE is a potential non-invasive quantitative assessment tool for PD.
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spelling pubmed-98582142023-01-21 Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography Oppold, Julia Breu, Maria-Sophie Gharabaghi, Alireza Grimm, Alexander Del Grosso, Nicholas A. Hormozi, Mohammad Kleiser, Benedict Klocke, Philipp Kronlage, Cornelius Weiß, Daniel Marquetand, Justus Diagnostics (Basel) Article Rigidity in Parkinson’s disease (PD) is assessed by clinical scales, mostly the Unified Parkinson’s Disease Rating Scale of the Movement Disorders Society (MDS-UPDRS). While the MDS-UPDRS-III ranges on an integer from 0 to 4, we investigated whether muscle ultrasound shear wave elastography (SWE) offers a refined assessment. Ten PD patients (five treated with deep brain stimulation (DBS) and levodopa, five with levodopa only) and ten healthy controls were included. Over a period of 80 min, both the SWE value and the item 22b-c of the MDS-UPDRS-III were measured at 5 min intervals. The measurements were performed bilaterally at the biceps brachii muscle (BB) and flexor digitorum profundus muscle in flexion and passive extension. Rigidity was modified and tracked under various therapeutic conditions (with and without medication/DBS). The feasibility of SWE for objective quantification was evaluated by correlation with the UPDRS-III: considering all positions and muscles, there was already a weak correlation (r = 0.01, p < 0.001)—in a targeted analysis, the BB in passive extension showed a markedly higher correlation (r = 0.494, p < 0.001). The application of dopaminergic medication and DBS resulted in statistically significant short-term changes in both clinical rigidity and SWE measurements in the BB (p < 0.001). We conclude that rigidity is reflected in the SWE measurements, indicating that SWE is a potential non-invasive quantitative assessment tool for PD. MDPI 2023-01-06 /pmc/articles/PMC9858214/ /pubmed/36673022 http://dx.doi.org/10.3390/diagnostics13020213 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oppold, Julia
Breu, Maria-Sophie
Gharabaghi, Alireza
Grimm, Alexander
Del Grosso, Nicholas A.
Hormozi, Mohammad
Kleiser, Benedict
Klocke, Philipp
Kronlage, Cornelius
Weiß, Daniel
Marquetand, Justus
Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title_full Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title_fullStr Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title_full_unstemmed Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title_short Ultrasound of the Biceps Muscle in Idiopathic Parkinson’s Disease with Deep Brain Stimulation: Rigidity Can Be Quantified by Shear Wave Elastography
title_sort ultrasound of the biceps muscle in idiopathic parkinson’s disease with deep brain stimulation: rigidity can be quantified by shear wave elastography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858214/
https://www.ncbi.nlm.nih.gov/pubmed/36673022
http://dx.doi.org/10.3390/diagnostics13020213
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