“Losing the Brakes”—Suppressed Inhibitors Triggering Uncontrolled Wnt/ß-Catenin Signaling May Provide a Potential Therapeutic Target in Elderly Acute Myeloid Leukemia

Dysregulated Wnt/β-catenin signal transduction is implicated in initiation, propagation, and poor prognosis in AML. Epigenetic inactivation is central to Wnt/β-catenin hyperactivity, and Wnt/β-catenin inhibitors are being investigated as targeted therapy. Dysregulated Wnt/β-catenin signaling has als...

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Detalles Bibliográficos
Autores principales: Elyamany, Ghaleb, Rizwan, Hassan, Akhter, Ariz, Aljabry, Mansour S., Alotaibi, Sultan, Albalawi, Mohammad A. Hameed, Shabani-Rad, Meer-Taher, Roshan, Tariq Mahmood, Mansoor, Adnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858232/
https://www.ncbi.nlm.nih.gov/pubmed/36661526
http://dx.doi.org/10.3390/cimb45010040

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