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Clinical and Laboratory Diagnosis of Legionella Pneumonia
Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858276/ https://www.ncbi.nlm.nih.gov/pubmed/36673091 http://dx.doi.org/10.3390/diagnostics13020280 |
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author | Bai, Lu Yang, Wei Li, Yuanyuan |
author_facet | Bai, Lu Yang, Wei Li, Yuanyuan |
author_sort | Bai, Lu |
collection | PubMed |
description | Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden. |
format | Online Article Text |
id | pubmed-9858276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98582762023-01-21 Clinical and Laboratory Diagnosis of Legionella Pneumonia Bai, Lu Yang, Wei Li, Yuanyuan Diagnostics (Basel) Review Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden. MDPI 2023-01-12 /pmc/articles/PMC9858276/ /pubmed/36673091 http://dx.doi.org/10.3390/diagnostics13020280 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bai, Lu Yang, Wei Li, Yuanyuan Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title_full | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title_fullStr | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title_full_unstemmed | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title_short | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
title_sort | clinical and laboratory diagnosis of legionella pneumonia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858276/ https://www.ncbi.nlm.nih.gov/pubmed/36673091 http://dx.doi.org/10.3390/diagnostics13020280 |
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